Studies carried out on individuals being treated long
term with bisphosphonates have provoked considerable interest
and perplexity about the effect that these drugs have on bone
turnover in the long run.
In fact the experiences reported by numerous researchers
tend to highlight how treatment with high doses of bisphosphonates
over many years, of individuals with osteoporosis complicated
by or secondary to neoplastic pathologies, causes a
suppression of bone turnover that over time predisposes the
bone to the accumulation of micro damage that can then result
in complicated fractures, as in the case described here
