open7noembargoed_20180701Valente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, AlessandroValente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, Alessandr

Astolfi, Laura

Chicca, Milvia

DANTI, SERENA

Franceschini, Valeria

Martini, Alessandro

Simoni, Edi

Valente, Filippo

English

Local drug delivery based on nanoparticles (NP) represents a novel strategy to improve inner ear treatments. The intratympanic delivery of NP may be suitable to treat or prevent hearing loss originating from damage to hair cells and spiral ganglion neurons in the cochlea. Numerous experimental studies support in&nbsp;vitro and in&nbsp;vivo the biocompatibility of NP, their physical stability, target specificity, cell/tissue uptake and ability to internalize therapeutic agents. The topical use of NP helps to reduce the amount of drug required and avoid systemic side effects. This review focuses on recent findings and applications of different NP systems locally delivered to the inner ear. The perspectives for clinical application of NP in inner ear drug delivery are also discussed

Archivio della Ricerca - Università di Pisa

Nanoparticle drug delivery systems for inner ear therapy: An overview

Filippo Valente

Laura Astolfi

Edi Simoni

Serena Danti

Valeria Franceschini

Milvia Chicca

Alessandro Martini

Crossref

Journal of Drug Delivery Science and Technology

VALENTE, FILIPPO

ASTOLFI, LAURA

SIMONI, EDI

Danti, Serena

MARTINI, ALESSANDRO

Archivio istituzionale della ricerca - Università di Padova

Padua Research Archive

https://www.research.unipd.it/bitstream/11577/3223176/2/JDDST_2017_23_Revision%201_V0.pdf

Nanoparticle drug delivery systems for inner ear therapy: An overview

Abstract

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Archivio della Ricerca - Università di Pisa

Crossref

Archivio istituzionale della ricerca - Università di Padova

Padua Research Archive