Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond

Abstract

External beam radiation therapy (EBRT) plays a central role in the management of high-grade gliomas, both for curative and palliative intent. Advances in treatment strategies have improved patient survival; therefore neurotoxicity became a significant problem. The use of ionizing radiations results in malignant cell damage and induces deterministic or stochastic side effects on normal tissues