Primary care is in a unique position to teach the broad spectrum of differential diagnoses. We developed and piloted a new elective seminar ‘Differential Diagnosis in Primary Care’. With the help of simulation patients, training models, interactive small group work, and short lectures we addressed common complaints presented in the daily routine of primary care like vertigo, dyspnoea, chest or abdominal pain. We put a special focus on the diagnostic accuracy of history and physical examination. The final examination was conducted as an objective structured clinical examination