Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients
Aims. Patients with diabetic nephropathy are reported to have a high prevalence of left
ventricular structural and functional abnormalities. This study was designed to assess
the determinants of left ventricular mass index (LVMI) and left ventricular ejection
fraction (LVEF) in diabetic patients at various stages of chronic kidney disease
(CKD).
Methods. This cross-sectional study enrolled 285 diabetic patients with CKD stages 3
to 5 from our outpatient department of internal medicine. Clinical and
echocardiographic parameters were compared and analyzed.
Results. We found a significant stepwise increase in LVMI (P < 0.001), LVH (P < 0.001), and LVEF <55% (P = 0.013) and a stepwise decrease in LVEF (P = 0.038)
corresponding to advance in CKD stages.
Conclusions. Our findings suggest that increases in LVMI and decreases in LVEF coincide
with advances in CKD stages in patients with diabetes