High-throughput genotyping and increased
availability of electronic health records (EHR) are giving
scientists the unprecedented opportunity to exploit routinely
generated clinical data to advance precision medicine. The
extent to which national structured EHR in the United Kingdom
can be utilized in genome-wide association studies (GWAS) has
not been systematically examined. In this study, we evaluate the
performance of an EHR-derived acute myocardial infarction
phenotype (AMI) for performing GWAS in the UK Biobank
