Bebbington, P

Bonetto, C

Cremonese, C

Cristofalo, D

de Girolamo, G

Kuipers, E

Meneghelli, A

Miceli, M

Onwumere, J

Ruggeri, M

Scarone, S

UCL Discovery

Identifying Moderators and Predictors of Treatment Outcome in Caregivers. Results from the GET UP PIANO Pragmatic Cluster Randomized Controlled Trial  Juliana Onwumere1, Elisabeth Kuipers1, Paul Bebbington2, Chiara Bonetto3, Doriana Cristofalo2, Carla Cremonese4, Maurizio Miceli5, Silvio Scarone6, Anna Meneghelli7, Giovanni de Girolamo8, Mirella Ruggeri3, The GET UP Group3  1King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Department of Psychology, London, UK, 2University College London, Department of Mental Health Sciences, 3Unversity of Verona, Italy, 4ULSS15 Padova, 5AUSL of Florence, Florence, Italy, 6University of Milano, Milan, Italy, 7Azienda Ospedaliera Niguarda ca Grande Milano, Italy, 8IRCCS Fatebenefratelli – Brescia, Italy  Background: Over the last decade, family interventions (FI) and cognitive behavioural therapy(CBT) have featured in psychosis treatment guidelines in different countries and alongside case management, form part of optimal packages of care in first episode psychosis (FEP) services. Robust evidence in support of their efficacy and acceptability to clinical groups is well established. However, data remains scarce and our understanding limited, on moderators of treatment outcome for carers in FEP services. This study investigated what carer and patient demographics and clinical profiles were associated with gains from psychosocial treatment interventions within FEP services. Methods: Data was collected as part of the GET UP (Genetics, Endophenotypes, Treatment: Understanding early Psychosis) PIANO (Psychosis: early intervention and Assessment of Needs and Outcome) pragmatic cluster RCT that compared additional psychosocial intervention (CBT, FI case management) with treatment as usual for FEP cases in 126 mental health centres in Italy. Patients were assessed with a range of clinical assessments before treatment initiation and 9 month follow up. Results: Significant interactions were identified between psychosocial interventions, patient and carer factors and carer outcomes. The results suggested that psychosocial interventions, when compared to routine care alone, delivered greater reductions in carer distress particularly in patients reporting higher levels of carer EE and more negative accounts of early caregiving experiences and carers reporting greater caregiving hours. Further analyses are in progress. Conclusions: Current findings are encouraging and offer indications for future investigations. Further studies are required to replicate the findings and assess the contribution of local contexts.  

Identifying Moderators and Predictors of Treatment Outcome in Caregivers. Results from the GET UP PIANO Pragmatic Cluster Randomized Controlled Trial

http://discovery.ucl.ac.uk/1531446/1/Bebbington_Onwumere%2520et%2520al%25202016Identifying%2520Moderators%2520and%2520Predictors%2520of%2520Treatment%2520Outcome%2520in%2520Caregivers.pdf

Identifying Moderators and Predictors of Treatment Outcome in Caregivers. Results from the GET UP PIANO Pragmatic Cluster Randomized Controlled Trial

Abstract

Similar works

Full text

Available Versions

UCL Discovery