Septic shock is a major cause of death among
patients in intensive care units worldwide. Despite the
recent developments and progression in medical research,
sepsis remains a challenge. Multiple‐organ failure including
brain dysfunction (septic encephalopathy) is the
predominant cause of death in septic patients. Elevations of
cytokine concentrations in the brain have been described in
both experimental and clinical studies. Furthermore,
mitochondrial dysfunction has also been described in septic
encephalopathy. Since also sedative drugs interfere with
brain function, they may contribute to septic
encephalopathy
