A Bogdan

A Bottomley

A Korszun

A Sadeh

A Satlin

AM Berger

Carol Ferrans

CE Ferrans

Christine M Ansell

Christopher G Lis

CS Cleeland

D Gupta

D Walsh

Digant Gupta

Dinah Faith T Quiton

Donald P Braun

E Filipski

E Souetre

Eun Young Oh

F Halberg

F Murphy

G Jean-Louis

I Iurisci

IB Wilson

IN Karatsoreos

J Aschoff

James F Grutsch

JD Lin

JE Ferrie

Jovelyn Du-Quiton

JR Davidson

Justin L Reynolds

K Mystakidou

M Mackiewicz

Mary Ann Daehler

MC Mormont

MJ Hjermstad

NK Aaronson

NW Scott

P Hunter

Patricia A Wood

PD Penev

R Wever

RD Levin

RE Salas

RG Foster

RJ Cole

Robert D Levin

RY Moore

S Ancoli-Israel

S Ancoli-Isreal

S Bentley

S Mercadante

S Panda

SE Sephton

SL Beck

T Nakamura

T Rich

TA Rich

TC Erren

WHE Hrushesky

William JM Hrushesky

WJ Hrushesky

Y Le Guen

YM Lin

BMC Cancer

English

PubMed

Springer - Publisher Connector

The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer

Abstract
          
            Background
            Cancer patients routinely develop symptoms consistent with profound circadian disruption, which causes circadian disruption diminished quality of life. This study was initiated to determine the relationship between the severity of potentially remediable cancer-associated circadian disruption and quality of life among patients with advanced lung cancer.
          
          
            Methods
            We concurrently investigated the relationship between the circadian rhythms of 84 advanced lung cancer patients and their quality of life outcomes as measured by the EORTC QLQ C30 and Ferrans and Powers QLI. The robustness and stability of activity/sleep circadian daily rhythms were measured by actigraphy. Fifty three of the patients in the study were starting their definitive therapy following diagnosis and thirty one patients were beginning second-line therapy. Among the patients who failed prior therapy, the median time between completing definitive therapy and baseline actigraphy was 4.3 months, (interquartile range 2.1 to 9.8 months).
          
          
            Results
            We found that circadian disruption is universal and severe among these patients compared to non-cancer-bearing individuals. We found that each of these patient's EORTC QLQ C30 domain scores revealed a compromised capacity to perform the routine activities of daily life. The severity of several, but not all, EORTC QLQ C30 symptom items correlate strongly with the degree of individual circadian disruption. In addition, the scores of all four Ferrans/Powers QLI domains correlate strongly with the degree of circadian disruption. Although Ferrans/Powers QLI domain scores show that cancer and its treatment spared these patients' emotional and psychological health, the QLI Health/Function domain score revealed high levels of patients' dissatisfaction with their health which is much worse when circadian disruption is severe. Circadian disruption selectively affects specific Quality of Life domains, such as the Ferrans/Powers Health/Function domain, and not others, such as EORTC QLQ C30 Physical Domain.
          
          
            Conclusions
            These data suggest the testable possibility that behavioral, hormonal and/or light-based strategies to improve circadian organization may help patients suffering from advanced lung cancer to feel and function better.
          </jats:sec

Crossref

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3114794

The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector

Crossref