Authors/Task Force Members

B. Y. Cha

C. W. Ahn

Cardoso

D. J. Lim

Dyck

E. S. Kim

Forsblom

H. S. Kwon

H. Y. Son

H.-S. Kim

J. H. Cho

K. H. Yoon

Laurent

M. I. Kang

Meyer

Ogawa

S.-d. Moon

Shirai

Tesfaye

Viswanathan

Yokoyama

English

PubMed


                  OBJECTIVE
                  This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima–media thickness (IMT).
               
               
                  RESEARCH DESIGN AND METHODS
                  We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography.
               
               
                  RESULTS
                  Patients with DPN had higher CAVI than those without DPN in multivariate-adjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In the multivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% CI 1.13–1.65], P = 0.001).
               
               
                  CONCLUSIONS
                  DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.
               </jats:sec

Eun Sook Kim

Sung-dae Moon

Hun-Sung Kim

Dong Jun Lim

Jae Hyoung Cho

Hyuk Sang Kwon

Chul Woo Ahn

Kun Ho Yoon

Moo Il Kang

Bong Yun Cha

Ho Young Son

Crossref

Diabetes Care

Diabetic Peripheral Neuropathy Is Associated With Increased Arterial Stiffness Without Changes in Carotid Intima–Media Thickness in Type 2 Diabetes

Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC);

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3114324

Diabetic Peripheral Neuropathy Is Associated With Increased Arterial Stiffness Without Changes in Carotid Intima–Media Thickness in Type 2 Diabetes

Abstract

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