Arama, V

Gliga, S

Hristea, A

Ion, M

Mihailescu, R

Moroti, R

Olaru, I

Petre, R

Popescu, C

Radulescu, M

English

PubMed

A Hristea

R Petre

S Gliga

I Olaru

M Ion

R Moroti

C Popescu

R Mihailescu

M Radulescu

V Arama

Crossref

Journal of the International AIDS Society

The management of acute retroviral syndrome

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POSTER PRESENTATION Open Access
The management of acute retroviral syndrome
A Hristea*, R Petre, S Gliga, I Olaru, M Ion, R Moroti, C Popescu, R Mihailescu, M Radulescu, V Arama
From Tenth International Congress on Drug Therapy in HIV Infection
Glasgow, UK. 7-11 November 2010
Background
Guidelines recommend starting treatment in HIV infected
patients earlier than before, but there is no consensus on
the exact moment when treatment should be initiated.
Would treatment started and maintained in patients with
acute retroviral syndrome, make an impact on disease pro-
gression, and outcome?
Study objective
to follow and assess patients diagnosed with acute ret-
roviral syndrome (ARS) in our facility and evaluate
short-term differences between patients on continuous
antiretroviral treatment and patients who were treated
only during the acute phase.
Materials and methods
A retrospective study of patients diagnosed with ARS in
our facility between 1999-2009, who had previously
tested negative at an ELISA test and consequently had a
positive or negative ELISA and a viral load of over
10.000 copies/ml were included in the study. Patients
were divided into two groups: patients who were only
treated initially and then therapy was stopped (group 1)
and patients who continued treatment (group 2).
Results
Sixteen patients met the criteria (11 males and 5
females), median age of 28.5 years. Eleven were diag-
nosed after 2005. Patients were followed for a median
duration of 42 months (12-132 months). Five patients
were included in the first group and 11 in group 2.
Median age of patients was higher in group 1 vs group
2 (34 vs 25 years). Symptoms and signs reported at diag-
nosis were: fatigue (16 patients), fever (12), dysphagy
(12), lymph node enlargement (10), rash (10), myalgias
(8), exudative pharyngitis (6), thrush (6), oral ulcerations
(6), weight loss (6), meningitis (4) and genital ulcers (2).
The median CD4 count at diagnosis was 394 cells/mm3
(range 123-1184 cells/mm3) and the median viral load
was 772000 copies/ml. The total duration of antiretro-
viral therapy (ARVT) was between 12 and 100 months.
The median CD4 count at the last evaluation was higher
in group 2 (579 cells/mm3) vs group 1 (467 cells/mm3),
but the rise in CD4 count during follow-up did not dif-
fer significantly between groups, since patients in group
2 had a median CD4 count on inclusion of 397 cells/
mm3 vs 280 cells/mm3 in group 1. Median viral load in
patients without ARVT was 6358 copies/ml while in
those under therapy was undetectable.
Conclusions
Even though the follow up period was relatively short
(median of 72 months for group 1 and 27 months for
group 2) continuing therapy after the acute phase did
not have an impact on the immunological status of the
patients.
Published: 8 November 2010
doi:10.1186/1758-2652-13-S4-P2
Cite this article as: Hristea et al.: The management of acute retroviral
syndrome. Journal of the International AIDS Society 2010 13(Suppl 4):P2.
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Hristea et al. Journal of the International AIDS Society 2010, 13(Suppl 4):P2
http://www.jiasociety.org/content/13/S4/P2
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The management of acute retroviral syndrome

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