Bertman, Kathleen

Kadiyala, Madhavi

Pollack, Simcha

Reichek, Nathaniel

Toole, Rena

English

PubMed

Madhavi Kadiyala

Rena Toole

Kathleen Bertman

Simcha Pollack

Nathaniel Reichek

Crossref

POSTER PRESENTATION Open AccessFeature Tracking: a novel method to analyzemyocardial strain: Results from the CMR strainstudy in healthy volunteersMadhavi Kadiyala*, Rena Toole, Kathleen Bertman, Simcha Pollack, Nathaniel ReichekFrom 2011 SCMR/Euro CMR Joint Scientific SessionsNice, France. 3-6 February 2011ObjectiveWe sought to determine normal gender-specific strainvalues in healthy subjects using Feature Tracking (FT-MRI).BackgroundFeature tracking (FT-MRI) is a novel MRI based methodto analyze myocardial strain that is fast, simple and haspotential for clinical use. Similar to echocardiographic“speckle tracking” myocardial “features” can be trackedon routine steady state free precession or gradient echoimages without the need for additional tagged imaging.MethodsGlobal and regional strains including circumferential(endocardial and epicardial Ecc), radial (Err) and longi-tudinal (Ell) strains were obtained with FT-MRI (Dio-genes v Tomtec Systems) in 60 carefully screenednormal subjects. Strains were derived from three longSaint Francis Hospital, The Heart Center, Roslyn, NY, USAFigure 1Kadiyala et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P14http://jcmr-online.com/content/13/S1/P14© 2011 Kadiyala et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative CommonsAttribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction inany medium, provided the original work is properly cited.axis (four, three and two chamber) and three short axisviews (basal, mid and apical ) after semi automated tra-cing of endocardial and epicardial borders. Strains weremapped to a 17 segment AHA model and regionalstrains in the left anterior descending (LAD), circumflex(LCX) and right coronary (RCA) territories derived.ResultsThere were 29 men and 31 women with mean age 54(14) yrs. The peak global strains were : Ecc (endo) -24(4)%, Ecc (epi)-16(3)%( difference p <0.0001), Ell : -16(5)% and Err : 15(6)%. There was a significant mid toapical gradient in both Ecc (endo) and Ecc (epi) (Δ 4.4,p < 0.0001; Δ3.8, p <0.0001) and Ell (Δ 3, p =0.05), butno significant gradient was present in Err. The septumhad the lowest Err (8.6(6)% ), while the lateral wall hadthe highest Err (23.9(9)%) . Err was highest in the LCXterritory. Ecc, and Ell were lowest in the RCA territory.Ecc and Ell were generally higher in women than inmen, while global Err was lower in women (fig). Therewas no significant relationship between the globalstrains and age, blood pressure, cholesterol levels, smok-ing history and family history of coronary disease. How-ever the strains were significantly associated with height(r 0.5, p0.0002), weight (r 0.44, p 0.002), left ventricularend diastolic volume (r 0.57, p <0.0001) and ejectionfraction (r -0.62, p <0.0001). Global Ecc (endocardial)correlated most closely with global ejection fraction(r=0.62, p<0.00001). Figure 1.ConclusionsFT-MRI is a novel MRI based method that providesconsistent values for global and regional strains in threedimensions from conventional MRI images. There is sig-nificant variation in global and regional strains amongmen and women. There is significant regional and cor-onary territory heterogeneity of strain patterns.Published: 2 February 2011doi:10.1186/1532-429X-13-S1-P14Cite this article as: Kadiyala et al.: Feature Tracking: a novel method toanalyze myocardial strain: Results from the CMR strain study in healthyvolunteers. Journal of Cardiovascular Magnetic Resonance 2011 13(Suppl 1):P14.Submit your next manuscript to BioMed Centraland take full advantage of: • Convenient online submission• Thorough peer review• No space constraints or color figure charges• Immediate publication on acceptance• Inclusion in PubMed, CAS, Scopus and Google Scholar• Research which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submitKadiyala et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P14http://jcmr-online.com/content/13/S1/P14Page 2 of 2

Journal of Cardiovascular Magnetic Resonance

Feature Tracking: a novel method to analyze myocardial strain: Results from the CMR strain study in healthy volunteers

Springer - Publisher Connector

POSTER PRESENTATION Open Access
Feature Tracking: a novel method to analyze
myocardial strain: Results from the CMR strain
study in healthy volunteers
Madhavi Kadiyala*, Rena Toole, Kathleen Bertman, Simcha Pollack, Nathaniel Reichek
From 2011 SCMR/Euro CMR Joint Scientific Sessions
Nice, France. 3-6 February 2011
Objective
We sought to determine normal gender-specific strain
values in healthy subjects using Feature Tracking (FT-MRI).
Background
Feature tracking (FT-MRI) is a novel MRI based method
to analyze myocardial strain that is fast, simple and has
potential for clinical use. Similar to echocardiographic
“speckle tracking” myocardial “features” can be tracked
on routine steady state free precession or gradient echo
images without the need for additional tagged imaging.
Methods
Global and regional strains including circumferential
(endocardial and epicardial Ecc), radial (Err) and longi-
tudinal (Ell) strains were obtained with FT-MRI (Dio-
genes v Tomtec Systems) in 60 carefully screened
normal subjects. Strains were derived from three long
Saint Francis Hospital, The Heart Center, Roslyn, NY, USA
Figure 1
Kadiyala et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P14
http://jcmr-online.com/content/13/S1/P14
© 2011 Kadiyala et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
axis (four, three and two chamber) and three short axis
views (basal, mid and apical ) after semi automated tra-
cing of endocardial and epicardial borders. Strains were
mapped to a 17 segment AHA model and regional
strains in the left anterior descending (LAD), circumflex
(LCX) and right coronary (RCA) territories derived.
Results
There were 29 men and 31 women with mean age 54
(14) yrs. The peak global strains were : Ecc (endo) -24
(4)%, Ecc (epi)-16(3)%( difference p <0.0001), Ell : -16
(5)% and Err : 15(6)%. There was a significant mid to
apical gradient in both Ecc (endo) and Ecc (epi) (Δ 4.4,
p < 0.0001; Δ3.8, p <0.0001) and Ell (Δ 3, p =0.05), but
no significant gradient was present in Err. The septum
had the lowest Err (8.6(6)% ), while the lateral wall had
the highest Err (23.9(9)%) . Err was highest in the LCX
territory. Ecc, and Ell were lowest in the RCA territory.
Ecc and Ell were generally higher in women than in
men, while global Err was lower in women (fig). There
was no significant relationship between the global
strains and age, blood pressure, cholesterol levels, smok-
ing history and family history of coronary disease. How-
ever the strains were significantly associated with height
(r 0.5, p0.0002), weight (r 0.44, p 0.002), left ventricular
end diastolic volume (r 0.57, p <0.0001) and ejection
fraction (r -0.62, p <0.0001). Global Ecc (endocardial)
correlated most closely with global ejection fraction
(r=0.62, p<0.00001). Figure 1.
Conclusions
FT-MRI is a novel MRI based method that provides
consistent values for global and regional strains in three
dimensions from conventional MRI images. There is sig-
nificant variation in global and regional strains among
men and women. There is significant regional and cor-
onary territory heterogeneity of strain patterns.
Published: 2 February 2011
doi:10.1186/1532-429X-13-S1-P14
Cite this article as: Kadiyala et al.: Feature Tracking: a novel method to
analyze myocardial strain: Results from the CMR strain study in healthy
volunteers. Journal of Cardiovascular Magnetic Resonance 2011 13(Suppl 1):
P14.
Submit your next manuscript to BioMed Central
and take full advantage of: 
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at 
www.biomedcentral.com/submit
Kadiyala et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P14
http://jcmr-online.com/content/13/S1/P14
Page 2 of 2


Feature Tracking: a novel method to analyze myocardial strain: Results from the CMR strain study in healthy volunteers

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