Adam, Gerhard

Barmeyer, Achim

Habermann, Christian R

Koester, Ralf

Koschyk, Dietmar

Lund, Gunnar K

Meier, Yasmin

Meinertz, Thomas

Muellerleile, Kai

Radunski, Ulf K

English

PubMed

Ulf K Radunski

Kai Muellerleile

Yasmin Meier

Christian R Habermann

Dietmar Koschyk

Ralf Koester

Gunnar K Lund

Gerhard Adam

Thomas Meinertz

Achim Barmeyer

Springer - Publisher Connector

POSTER PRESENTATION Open Access
Diastolic dysfunction in patients with preserved
ejection fraction: identification by velocity
encoded magnetic resonance imaging
Ulf K Radunski*, Kai Muellerleile, Yasmin Meier, Christian R Habermann, Dietmar Koschyk, Ralf Koester,
Gunnar K Lund, Gerhard Adam, Thomas Meinertz, Achim Barmeyer
From 2011 SCMR/Euro CMR Joint Scientific Sessions
Nice, France. 3-6 February 2011
Purpose
To evaluate the ability of velocity encoded (VENC)
magnetic resonance imaging (MRI) to identify patients
with diastolic dysfunction in comparison with Doppler-
echocardiography.
Introduction
Diastolic dysfunction was recently recognized as an
important cause for heart failure in patients with pre-
served ejection fraction. Diastolic dysfunction is typically
assessed in clinical routine using transmitral and pul-
monary-venous flow characteristics by Doppler-echocar-
diography. We hypothesized that VENC-MRI has a
similar ability to identify patients with diastolic dysfunc-
tion compared to Doppler-echocardiography.
Methods
The study included 76 patients with normal systolic left-
ventricular function and a high probability of diastolic
dysfunction. Transmitral flow and pulmonary venous
flow profiles were obtained by VENC-MRI and Doppler-
echocardiography. Measurements included maximal
early- and late-diastolic transmitral velocities (E- and
A-waves) as well as maximal systolic and diastolic pul-
monary venous velocities (S- and D-wave). Furthermore,
VENC-MRI was used to assess total diastolic left ventri-
cular (LV) filling as well as the early and late portions of
diastolic LV filling.
Results
Doppler-echocardiography identified 38 patients with
diastolic dysfunction. 24 patients had grade I diastolic
dysfunction, 8 patients hat grade II diastolic dysfunction
and 3 patients had grade 3 diastolic dysfunction. There
was a very good correlation between VENC-MRI and
Doppler-echocardiography for the E/A-ratio using peak
velocities (r=0.73, P<0.0001). A moderate correlation was
found for the S/D-ratio between VENC-MRI and
Doppler-echocardiography using peak velocities (r=0.54,
P<0.01). In grade I diastolic dysfunction, the contribution
of early LV filling to total LV filling was significantly
lower compared to patients with normal diastolic func-
tion or higher grades of diastolic dysfunction (Figure 1).
University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Figure 1
Radunski et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P330
http://jcmr-online.com/content/13/S1/P330
© 2011 Radunski et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
Conclusions
VENC-MRI has the ability to identify diastolic dysfunc-
tion by measurements of transmitral flow velocities.
Furthermore, the assessment of early and late LV diasto-
lic filling volumes may provide additional information
for the grading of diastolic dysfunction.
Published: 2 February 2011
doi:10.1186/1532-429X-13-S1-P330
Cite this article as: Radunski et al.: Diastolic dysfunction in patients with
preserved ejection fraction: identification by velocity encoded magnetic
resonance imaging. Journal of Cardiovascular Magnetic Resonance 2011 13
(Suppl 1):P330.
Submit your next manuscript to BioMed Central
and take full advantage of: 
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at 
www.biomedcentral.com/submit
Radunski et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P330
http://jcmr-online.com/content/13/S1/P330
Page 2 of 2


Diastolic dysfunction in patients with preserved ejection fraction: identification by velocity encoded magnetic resonance imaging

Diastolic dysfunction in patients with preserved ejection fraction: identification by velocity encoded magnetic resonance imaging

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector

Directory of Open Access Journals

Springer - Publisher Connector

Crossref