Francois Mach

Gabriella M Vincenti

Jean-Noel Hyacinthe

Jean-Paul Vallée

JJ Zwanenburg

Joost PA Kuijer

JP Jacob

M Stuber

Osman Ratib

Thomas Schindler

Journal of Cardiovascular Magnetic Resonance

English

PubMed

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Assessment of left ventricular apical rotation in obese by Cardiovascular MR tagging

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POSTER PRESENTATION Open Access
Assessment of left ventricular apical rotation in
obese by Cardiovascular MR tagging
Gabriella M Vincenti1*, Jean-Noel Hyacinthe2, Joost PA Kuijer3, Francois Mach1, Osman Ratib4, Thomas Schindler1,
Jean-Paul Vallée2
From 2011 SCMR/Euro CMR Joint Scientific Sessions
Nice, France. 3-6 February 2011
Background
Obesity is associated with cardiac remodelling with
increased left ventricular mass and end-diastolic volume.
CMR is a unique technique to evaluate cardiac mor-
phology and function in obese individuals. Among CMR
techniques, myocardial tagging allows to quantify myo-
cardial strain and left ventricular rotation along the RR
cycle (1). The aim of this preliminary study was to
explore the feasibility of left ventricular apical rotation
quantification by CMR tagging in obese individuals and
exploring possible alteration of myocardial motion
pattern.
Methods
8 healthy controls (18<BMI<25) were imaged using a 3T
trio system and 7 obese subjects (BMI>30) without
other cardiovascular risk factors and with normal left
ventricular ejection fraction were imaged using a 1.5T
Espree system (wider bore, well adapted to obese sub-
jects). We used an ECG gated, single breath hold
balanced SSFP line tagging sequence with LISA, with
CSPAMM acquisition scheme (2). The field of view was
340 x340 mm, matrix 256 with 32% phase resolution,
bandwidth 850 Hz, slice thickness 7 mm, tag spacing
7 mm, TE 1.28 (TE 1.54 @ 3T) and Flip angle 20° (15°
@ 3T). Images were analyzed and apical rotations were
computed using Extrema Temporal Chaining (ETC) (3).
Results
The left ventricular apical systolic rotation measured by
CMR tagging was increased and delayed in obese
patients while the diastolic apical untwisting was
prolonged, when compared to control subjects (Fig.1).
Conclusions
Our preliminary results confirm the presence of an
abnormal pattern of left ventricular rotation in obese
individuals that can be identified with CMR tagging.
This abnormal pattern may reflect the remodeling sec-
ondary to increased hemodynamic requirements
(volume-overload and sympathetic system activation) in
obese subjects, while the delayed diastolic untwisting
may precede a diastolic dysfunction. These preliminary
data confirm that CMR with myocardial tagging may
allow identifying early abnormalities of left ventricular
function in obese individuals with normal left ventricu-
lar ejection fraction.
Author details
1Division of Cardiology, Geneva University Hospital, Geneva, Switzerland.
2Division of Radiology, Geneva University Hospital, Geneva, Switzerland.
1Division of Cardiology, Geneva University Hospital, Geneva, Switzerland
Full list of author information is available at the end of the article
Figure 1 Left ventricular apical rotation along RR interval in Obese
and control subjects.
Vincenti et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P326
http://jcmr-online.com/content/13/S1/P326
© 2011 Vincenti et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
3Department of Physics & Medical Technology, VU University Medical Center,
Amsterdam, Netherlands. 4Division of Nuclear Medecine, Geneva University
Hospital, Geneva, Switzerland.
Published: 2 February 2011
References
1. Stuber M, et al: Circulation 1999, 100(4):361-8.
2. Zwanenburg JJ, et al: Magn Reson Med 2003, 49(4):722-30.
3. Jacob JP: LNCS 2006, 4179:897-908.
doi:10.1186/1532-429X-13-S1-P326
Cite this article as: Vincenti et al.: Assessment of left ventricular apical
rotation in obese by Cardiovascular MR tagging. Journal of
Cardiovascular Magnetic Resonance 2011 13(Suppl 1):P326.
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Vincenti et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P326
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Cite this article as: Vincenti et al.: Assessment of left ventricular apical rotation in obese by Cardiovascular MR tagging.

Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance

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Assessment of left ventricular apical rotation in obese by Cardiovascular MR tagging

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