A Hiller

Andréas Moser

C Börgers

Félix Njap

JA Obeso

RL Albin

Simon Vogt

T L Li

Ulrich Hofmann

BMC Neuroscience

English

PubMed

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Computational modeling of Basal Ganglia: towards a mechanism of high frequency stimulation

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POSTER PRESENTATION Open Access
Computational modeling of Basal Ganglia:
towards a mechanism of high frequency
stimulation
Félix Njap1,2*, Andréas Moser3, Simon Vogt1, Ulrich Hofmann1
From Nineteenth Annual Computational Neuroscience Meeting: CNS*2010
San Antonio, TX, USA. 24-30 July 2010
Deep Brain Stimulation(DBS) with 130Hz represents an
effective therapy to alleviate symptoms of some neuro-
degenerative diseases such as Parkinson syndrome [1].
However the mechanism underlying the observed
improvement in patient’s symptoms is still under dis-
pute. Modeling of its mechanism was first done with the
Albin-Delong [2] model, which assumed two discrimi-
nated feedforward projections, from the input stage
Striatum to the output stage Globus pallidus internal
(GPi) and Substantia Nigra pars reticulata (SNr). How-
ever, this influential contribution neither took motor
control into account nor the evidence for a selective of
effect high frequency stimulation [3-5]. This study tries
to model the underlying network with increasing realis-
tic complexity and presents a spiking network model
based on Izhikevich type neurons [6]. Our currently
simulated model examines the firing patterns variability
between GABAergic STN neuron projections depending
on the firing rate. It shows features like synchronous,
rythmic population spike found in experimental data of
pyramidal interneuronal network [7].
Acknowledgement
This work was supported by the Graduate School for Computing in
Medicine and Life Sciences funded by Germany’s Excellence Initiative
[DFG GSC 235/1].
Author details
1Institute for Signal Processing, University of Lübeck, Lübeck, D-23538,
Germany. 2Graduate School for Computing medicine and Life Sciences,
Lübeck, D-23538, Germany. 3Department of Neurology, University of Lübeck,
Lübeck, D-23538, Germany.
Published: 20 July 2010
References
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Deep-brain stimulation of the subthalamic nucleus or the pars interna
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345:956-63.
2. Albin RL, Young AB, Penney JB: The functional anatomy of basal ganglia
disorders. Trends Neurosci 1989, 12:366-375.
3. Hiller A, Loeffler S, Haupt Ch, Litza M, Hofmann U, Moser A: Electrical High
Frequency Stimulation Induces GABA Outflow in Freely Moving Rats.
J Neurosci Methods 2007, 159:286-290.
4. Li T L, Thümen A, Moser A: Modulation of a neuronal network by
electrical high frequency stimulation in striatal slices of the rat in vitro.
Neurochem. Int. 2006, 48:83-86.
5. Mantovani M, Haas CA, Zentner J, Moser A, Feuerstein TJ: GABAA
autoreceptors enhance GABA release from human neocortex: towards a
mechanism for high-frequency stimulation (HFS) in brain.
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Netw 2003, 14(6).
7. Börgers C, Kopell N: Synchronization in Networks of Excitatory and
Inhibitory Neurons with Sparse, Random connectivity. Neural Comput
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doi:10.1186/1471-2202-11-S1-P113
Cite this article as: Njap et al.: Computational modeling of Basal
Ganglia: towards a mechanism of high frequency stimulation. BMC
Neuroscience 2010 11(Suppl 1):P113.
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* Correspondence: njap@isip.uni-luebeck.de
1Institute for Signal Processing, University of Lübeck, Lübeck, D-23538,
Germany
Njap et al. BMC Neuroscience 2010, 11(Suppl 1):P113
http://www.biomedcentral.com/1471-2202/11/S1/P113
© 2010 Njap et al; licensee BioMed Central Ltd.


A: Electrical High Frequency Stimulation Induces GABA Outflow in Freely Moving Rats.

A: Modulation of a neuronal network by electrical high frequency stimulation in striatal slices of the rat in vitro.

AE: Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson’s disease.

Simple model of Spiking Meurons.

Synchronization in Networks of Excitatory and Inhibitory Neurons with Sparse, Random connectivity. Neural Comput

The functional anatomy of basal ganglia disorders. Trends Neurosci

TJ: GABAA autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3090814

Computational modeling of Basal Ganglia: towards a mechanism of high frequency stimulation

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