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Current Serum Lipoprotein Levels and fMRI Response to Working Memory in Midlife
Authors
Aartsen MJ
Alberti KG
+58 more
Andreana P. Haley
Bonarek M
Bondi MW
Bookheimer SY
Braver TS
Carmelli D
Castelli WP
Cox RW
Criqui MH
Czyzewski K
Danielle E. Eagan
DeKosky ST
Dik MG
Fedora O. Biney
Folstein MF
Gatto NM
Gonzales MM
Grundy SM
Haley AP
Haley AP
Haley AP
Hirofumi Tanaka
Ho R
Hofman A
Jacobs D
Kinosian B
Kivipelto M
Komulainen P
Kromhout D
Logothetis NK
Longstreth W
Lowenstein CJ
Mielke MM
Mineo C
Mitzi M. Gonzales
Morris JC
Navab M
Notkola IL
Owen AM
Pearson TA
Perticone F
Prince MJ
Ravizza SM
Reitan RM
Reynolds CA
Ridker PM
Ruff RM
Ruff RM
Scacchi R
Segura B
Singh-Manoux A
Solomon A
Takashi Tarumi
Tan ZS
Vita JA
White RP
Yaffe K
Yaffe K
Publication date
1 January 2011
Publisher
S. Karger AG
Doi
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on
PubMed
Abstract
Aims: Given that high cholesterol levels at midlife are a risk factor for future cognitive decline, the goal of the current study was to determine if cholesterol-related alterations in the cerebrovascular response to cognition could be detected at midlife. Methods: Forty adults, aged 40-60 years, performed a 2-Back working memory task during fMRI. The associations between serum total cholesterol, HDL-cholesterol, and total cholesterol/HDL-cholesterol concentrations to task-related activation intensity were modeled using multivariate multiple regression (two-tailed p \u3c 0.02). Results: Higher levels of total cholesterol/HDL-cholesterol related to reduced working memory-related activation intensity in the left inferior parietal lobe, right superior frontal gyrus, and right middle frontal gyrus. Conclusion: These data provide preliminary support for a deleterious effect of elevated total cholesterol/HDL-cholesterol ratio on cerebrovascular support for cognition in midlife. Copyright © 2011 S. Karger AG, Basel
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Last time updated on 23/07/2022
Crossref
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info:doi/10.1159%2F000324713
Last time updated on 11/12/2019