CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Survival of HIV-Infected Adolescents on Antiretroviral Therapy in Uganda: Findings from a Nationally Representative Cohort in Uganda
Authors
A Kiboneka
A Kiboneka
+23 more
Alexis Palmer
C Rongkavilit
Celestin Bakanda
CM Wilson
D Sauvageot
DA Murphy
DA Murphy
Edward J. Mills
JB Nachega
Jean B. Nachega
Josephine Birungi
Keith Chan
L Ferradini
M Charles
M May
MW Brinkhof
Nathan Ford
P Braitstein
PD Allison
PM Flynn
RA Ferrand
Robert Mwesigwa
Sarah Palmer
Publication date
1 January 2011
Publisher
Public Library of Science
Doi
View
on
PubMed
Abstract
CITATION: Bakanda, C. et al. 2011. Survival of HIV-infected adolescents on antiretroviral therapy in Uganda : findings from a nationally representative cohort in Uganda. PLoS ONE, 6(4): e19261, doi:10.1371/journal.pone.0019261.The original publication is available at http://journals.plos.org/plosoneBackground: Adolescents have been identified as a high-risk group for poor adherence to and defaulting from combination antiretroviral therapy (cART) care. However, data on outcomes for adolescents on cART in resource-limited settings remain scarce. Methods: We developed an observational study of patients who started cART at The AIDS Service Organization (TASO) in Uganda between 2004 and 2009. Age was stratified into three groups: children (≤10 years), adolescents (11-19 years), and adults (≥20 years). Kaplan-Meier survival curves were generated to describe time to mortality and loss to follow-up, and Cox regression used to model associations between age and mortality and loss to follow-up. To address loss to follow up, we applied a weighted analysis that assumes 50% of lost patients had died. Findings: A total of 23,367 patients were included in this analysis, including 810 (3.5%) children, 575 (2.5%) adolescents, and 21 982 (94.0%) adults. A lower percentage of children (5.4%) died during their cART treatment compared to adolescents (8.5%) and adults (10%). After adjusting for confounding, other features predicted mortality than age alone. Mortality was higher among males (p<0.001), patients with a low initial CD4 cell count (p<0.001), patients with advanced WHO clinical disease stage (p<0.001), and shorter duration of time receiving cART (p<0.001). The crude mortality rate was lower for children (22.8 per 1000 person-years; 95% CI: 16.1, 29.5), than adolescents (36.5 per 1000 person-years; 95% CI: 26.3, 46.8) and adults (37.5 per 1000 person-years; 95% CI: 35.9, 39.1). Interpretation: This study is the largest assessment of adolescents receiving cART in Africa. Adolescents did not have cART mortality outcomes different from adults or children. © 2011 Bakanda et al.http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019261Publisher's versio
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Stellenbosch University SUNScholar Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:scholar.sun.ac.za:10019.1/...
Last time updated on 27/05/2016
Public Library of Science (PLOS)
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 18/09/2018
Uganda Christian University Digital Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:ucudir.ucu.ac.ug:20.500.11...
Last time updated on 07/05/2019
Crossref
See this paper in CORE
Go to the repository landing page
Download from data provider
info:doi/10.1371%2Fjournal.pon...
Last time updated on 01/04/2019
Directory of Open Access Journals
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:doaj.org/article:74eb63133...
Last time updated on 13/10/2017
Cape Town University OpenUCT
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:open.uct.ac.za:11427/15000
Last time updated on 09/08/2016