Cocklin, Ross

Goebl, Mark

Korolev, Sergey

Lass, Agnieszka

Scaglione, Kenneth M

Skowyra, Dorota

Skowyra, Michael

English

PubMed

Digital Commons@Becker

The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2

A: S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.

A: The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition.

A: Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase. Invest Ophthalmol Vis Sci

AL: Certain pairs of ubiquitin conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

Algerghina L: The CK2 phosphorylation of catalytic domain of Cdc34 modulates its activity at the G1 to S transition in Saccharomyces cerevisiae. Cell Cycle

Bhaumik SR: Histone methylation and ubiquitination with their cross-talk and roles in gene expression and stability. Cell Mol Life Sci

Binding and recognition in the assembly of an active BRCA1/ BARD1 ubiquitin-ligase complex. Proc Natl Acad Sci USA

Cdc34 self-association is facilitated by ubiquitin thiolester formation and is required for its catalytic activity. Mol Cell Biol

Ciechanover A: The Ubiquitin System. Ann Rev Biochem

CP: Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution.

Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution. Biochemistry

D’Andrea A: Regulation of Fanconi aneamia pathway by monoubiquitination. Seminars in Cancer Biology

Deshaies RJ: Context of multiubiquitin chain attachment influences the rate of Sic1 degradation. Mol Cell

Deshaies RJ: Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. Cell

Deshaies RJ: Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Mol Biol Cell

Destabilization of binding to cofactors and SCFMet30 is the rate-limiting regulatory step in degradation of polyubiquitinated Met4. Mol Cell

Deubuquitinating PCNA: a downside to DNA damage tolerance.

Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes.

et al: Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science

F-box proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin Ligase Complex. Cell

Flow cytometric analysis of DNA content in budding yeast. Methods Enzymol

From loops to chains: unraveling the mysteries of polyubiquitin chain specificity and processivity.

Functional and physical characterization of the cell cycle ubiquitin-conjugating enzyme CDC34 (UBC3); Identification of a functional determinant within the tail that facilitates CDC34 self-association.

Fushman D: Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol

Goebl MG:

Goebl MG: An essential domain within Cdc34p is required for binding to a complex containing Cdc4p and Cdc53p in Saccharomyces cerevisiae.

Goebl MG: Intragenic suppression among CDC34 (UBC3) mutations defines a class of ubiquitin-conjugating catalytic domains. Mol Cell Biol

Grayhack EJ: A biochemical genomics approach for identifying genes by the activity of their products. Science

Hershko A: Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.

Hieter P: Methods in yeast genetics: a laboratory course manual.

Hochstrasser M: In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome.

Homology modeling by the ICM method. Proteins

Identification of a portable determinant of cell cycle function within the carboxyl-terminal domain of the yeast CDC34 (UBC3) ubiquitin conjugating (E2) enzyme.

JA: Global analysis of protein expression in yeast. Nature

Joazeiro C: RING domain ubiquitin E3 ligases. Annu Rev Biochem

KD: Regulation and Cellular Roles of Ubiquitin-specific Deubiquitinating Enzymes. Annu Rev Biochem

Klevit RE: A UbcH5/ ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination. Mol Cell

Klevit RE: Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.

Klevit RE: E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Nat Struct Mol Biol

Klevit RE: Ubiquitin transfer from the E2 perspective: why is UbcH5 so promiscuous? Cell Cycle

Mechanistic insights into active site-associated polyubiquitination by the ubiquitinconjugating enzyme Ube2g2. Proc Natl Acad Sci USA

MJ: A chimeric ubiquitin conjugating enzyme that combines the cell cycle properties of CDC34 (UBC3) and the DNA repair properties of RAD6 (UBC2): implications for the structure, function and evolution of the E2s.

New insights into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1. Genetics

Pan ZQ: Recruitment of a ROC1:

Pavletich NP: Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell

Pickart C: Recognition of the polyubiquitin proteolytic signal.

Pickart CM: Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat Struct Mol Biol

Pickart CM: Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths.

Pickart CM: Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of Isopeptidase T. Biochemistry

Protein regulation by monoubiquitination.

Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain. Nat Cell Biol

Rad23 and Rpn10: perennial wallflowers join the melee. TRENDS in Biochemical Sciences

RH: A deubiquitinating enzyme that disassembles free polyubiquitin chains is required for development but not growth in Dictyostelium.

RJ: A complex of

RJ: Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell

RJ: The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCF Cdc4. J Biol Chem

Sarcevic B: Cdc34 carboxy-terminal tail phosphorylation regulates SCF-mediated ubiquitination and cell cycle progression.

Sarcevic B: Mechanisms of mono- and poly-ubiquitination: ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine. Cell Division

Sarcevic B: Molecular Basis for Lysine Specificity in the yeast ubiquitin-conjugating enzyme Cdc34. Mol Cell Biol

SE: Expression and Localization of the CDC34 ubiquitin conjugating enzyme in Pediatric Acute Lymphoblastic Leukemia. Cell Growth and Differentiation

Skowyra D: ATP hydrolysis-dependent disassembly of the 26 S proteasome is part of the catalytic cycle. Cell

Skowyra D: Release of ubiquitin-charged Cdc34-S-Ub from the RING domain is essential for ubiquitination of the SCFCdc4-bound substrate Sic1. Cell

Skowyra D: SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo. Mol Cell Biol

The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science

Viestra RD: The ubiquitin-specific protease UBP14 is essential for early embrio development in Arabidopsis thaliana.

Xiong Y: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell

ZQ: Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization.

ZQ: Proximity-induced activation of human Cdc34 through heterologous dimerization. Proc Natl Acad Sci USA

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3080790

The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2

Abstract

Similar works

Full text

Available Versions

Digital Commons@Becker