2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Li, L

Qian, ZM

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t eraction mediated by lectin-like oxidized low-density lipoproteinreceptor-1[ J] .Proc Nat l Acad S ci USA , 2000, 97(1):360.[ 16] Li D , Meh ta JL.Upregulaiton of endothelial receptor for oxidizedLDL(LOX-1)by oxidized LDL and implications in apoptosis ofhuman coronary artery endothelial cells:evidence f rom use of an-t isense LOX-1 mRNA and chemical inhibi tors[ J] .Ar teriosclerThromb Vasc Biol , 2000 , 20(4):1116.[ 17] Cominacini L , Pasini AF , Garbin U , et a l.Oxidized low-densitylipoprotein(Ox-LDL)binding to Ox-LDL receptor-1 in endothe-lial cells induces the activat ion of NF-kB th rough an increasedproduction of in tracellular reactive oxygen species [ J] .J BiolChem ,2000 , 275(17):12633.[ 18] Li D , Meh ta JL.Ant isense to LOX-1 inhibi ts oxidized LDL-me-diated upregulat ion of monocyte chemoat t ractant p rotein-1 andmonocyte adhesion to human coronary artery endothelial cell[ J] .Circulat ion , 2000 , 101(25):2889.[ 19] Aoyama T , Chen MY , Fujiw ara H , et al.LOX-1 mediateslysophosphatidylcholine-induced oxidized LDL uptake in smoothmuscle cells[ J] .FEBS Let t , 2000 , 467(2-3):217.[ 20] Nagase M ,Hirose S , Saw amura T , et al.Enhanced expression ofendothelail oxidized low-density lipoprotein receptor(LOX-1)inhypertensive rat s[ J] .Biochem Biophys Res Commun , 1997 , 237(3):496.[ 21] Chen HJ , Li D , Saw amu ra T , et a l.Upregualtion of LOX-1 ex-pression in aorta of hypercholesterolemic rabbit s:modulation bylosartan[ J] .Biochem Biophys Res Comm un , 2000 , 276(3):1100.(????:2001-06-06)大豆异黄酮的药理作用和保健功能的研究进展李琳 ,钱忠明＊(??????????????????????? ,??)??:??　介绍大豆异黄酮药理作用和保健功能的研究进展。??　总结近 10 余年(1990 年以来)发表的 SCI 相关文章并进行分析。??　大豆异黄酮是一类具有雌激素样作用的非固醇类物质。 近年它的其他作用也已相继被发现。大量研究显示 ,这类物质具有多种保健和药理功效 , 包括抗肿瘤 、防止骨质疏松 、抗胆固醇和心血管保护等作用。??　雌激素样作用和抗氧化性质显示大豆异黄酮用于防治铁代谢紊乱引起的神经退行性疾病有良好前景。???:大豆异黄酮;雌激素样作用;抗氧化;神经退行性疾病;脑铁代谢?????:284.2 ?????:A ????:1001-2494(2002)10-0724-03????:???? RGC(A/ C:Polyu5270/ 01M/ B-Q445)???????????(A/ C:A-PC98 , A-PC23? G12.XX.93A2)????:?? ,? ,?? ,???　　＊????:??? ,? ,?? ,??? Tel:(852)27666694 E-mail:bczmqian@polyu.edu.hk　　?????(soybean isoflavone)???????????? ,?????????????????。???????????? ,???????? ,?????????。????????? ,?????????????????。???????????????????????? 、????? 、???????????????????????????? ,????????????。???????????????????????????。1　?????????????????????????????。?????????????????????????????(A ??B ?)?????。??????????????????。????????????????(genistein)??????(daidzein)??? β ???(?? A ?? 7 ????)??(genistin ? daidzin)。??????????????????? ,???????????[ 1] 。??????????????? , ???????????? , ???????。????????????????????。?????????????????????????????。????????????。????? ,??????。 —?????? ,?????????????????<40 nmol·L-1 。?????????????? ,???????? 7 ～ 110 ? , ????? 2.4 μmol·L-1[ 2] 。?? , Chang?[ 3]????????????????????。???????????????????(500 ? 5100 μg·g-1??)?? , ?????? 、??????????????????? ,???(4.26±0.29)?(2.97±0.14)h。 ?????(area under the concentration-time curve)?????? , ????(22.3±1.2)μmol·h·L-1 ,?????(45.6±3.1)μmol·h·L-1。???-????(endocrine-responsive tissues), ?? 、? 、?? 、?? 、??? 、?? 、?????????????????????????。???????????????(7.3 pmol·mg -1),?????????(0.04 pnmol·mg-1)。2　??? 、???????????????? ,?????????????????????(?? 17 ? β ???? 10-4 ～ 10-3)。?????????????? ,???????? , ????????????????。?????? , ??????? , ?????????????? , ????????? , ????·724· Chin Pharm J , 2002 October , Vol.37 No.10 　　　　　　　　　　　　 ?????? 2002? 10?? 37?? 10???????????[ 4] 。??????????? ,??????????(????????)????????????? ,?????????(????????)????????????。????????????????????? ,???????????????????[ 2] 。?????????????? , ?????? , ??????????? , ????????? , ?????????。??? , ????-?????????????[ 5]??????????????(β ??)???[ 6] ??????????????。?????? 、??????? ,?????????????[ 7]?????????β(transfomning grow th factorp , TGF β)???[ 8] , ???????????????。???????????????????? 、???????? 、??? S6 ??? DNA??????[ 9 ～ 10] 。3　???????????3.1　抗肿瘤??????? 、???????????? , ??????????????????[ 11] 。???????????(??? 620 ?? 243449 ?)???????? , ??????????????????。?????(1554?)?? ,?????????? 、???????????[ 12] 。?????????? , ???????????? HL-60 ?? , ?????? 5 ? 40 μmol·L -1???????????? 、??? 、?? 、?????????????????????。????????????? ,????????????? , ?????? , ?????????????。????????????????????????? , ??????????? , ????????????? TGF-β ???。??????????????????????????????[ 1 3] , ????????????????????????????? ,?????????。???????????????。3.2　预防骨质疏松???????????????????????????????????? ,???????????????。?? , ??????????????????[ 13] 。???? ,????????????????????。??????????(1 mg·d-1)2 ??????? , 5 ??????????????????????。Arjmandi?[ 14]?????? 、???????? 、??????(0.227 g·g -1??)??????????????。???? ,????????????????????? ,?????????。?????????????????????? ,?????????????。?????????????????????。?????? ,????????????? 40 g(??? 2.25 mg ?????), 6 ?????????????。????????????? 1.39 mg·g -1??? , ???????[ 15] 。????????????????。???? , ??????????????????????。????????????????????? ,???????????????????????。???????? 、???????? ,?????? TGF-β ?????。??????????? TGF-β ?? ,????????????????????????????。3.3　降胆固醇和心脏保护作用?????????????????????。 ??? 38 ???????????????????? , ????????????????。???? 47 g ???? ,??????????? 0.59 mmol·L-1(? 9.3%)。??????????????????????。????? ,??????????????? , ???????????。???????????????? , ??????????。???????? , ??????????????????????????。?? , ????????????????????????????。 ?????????????????? , ??????????? ,??????????????????。???????????????????????。????????????(45 mg/ 5 ～ 10 ?)??????????[ 16] 。???????????????????????????? ,????????????????? 。??????????????????? ,???????????。???????????????????????????????????? 、???????;?????????;??????;????????????????????????????????????????。????????????????????????????????[ 7] 。3.4　神经保护及抗神经退行性疾病???????? ,????????????? , ?????????????。????????????????[ 17] ??????[ 18] 。White ?[ 19] ?????????????????????? , ?????????????????? , ??????????。 T rieu ?Uckun ???[ 20]?? , ?????????????????????。?????????????? , ????????(????? 2∶1)。???????? 、?? 、??。???????(16 mg·kg-1 , bid)??????????? ,??????????????? , ???????????。??????????????????????????。??????????????????? ,????????? 16 mg·kg-1 6 , 24 h ?????????????????。????????? 、????????? ,???????????????。???·725·?????? 2002? 10?? 37?? 10?　　　　　　　　　　　 Chin Pharm J , 2002 October , Vol.37 No.10????????????????????????[ 7] 。????????????????????????[ 21] 。???????????????????????????????????。??????????? ,???????????????????????[ 22 ～ 23] 。??????????????????? , ?? ,??????????????????????????????。????????????????。 ?????????? ,?????? ,?????????。Ruiz-Larrea?[ 24]????? , ?????????????????? 。Wiseman ?[ 25]? 8-epi-???? F2α(??F 2-isoprostane , IsoPs)、?????????????????????????????。???? ,??????????? 8-epi-???? F2α???????????。 ???????????????????????????。????????????????????????????????。????[ 1] Boersma BJ , Patel RP , Kirk M , et al.Chlorinat ion and ni trat ionof soy isof lavones[ J] .Arch Biochem Biophys , 1999 , 368:265.[ 2] Adlercreutz H , M azur W.Phyto-estrogens and w estern disease[ J] .Ann Med , 1997 , 29:95.[ 3] Chang HC , Churchew ell M I , Delclos KB , et a l.Mass spect romet-ric determinat ion of genistein ti ssue dist ribut ion in diet-exposedSprague-Daw ley rats[ J] .J Nutr , 2000 , 130:1963.[ 4] Makela SI , Santt i R , Salo L , et al.Phytoest rogens are partial es-t rogen agonists in the adult male mouse[ J] .E nviron Health Per-spect , 1995 , 103:123.[ 5] McDonnell DP , Norris JD.Analysi s of the molecular pharmacolo-gy of est rogen receptor agonists and antagonist s p rovides insightsinto the mechanism of action of est rogen in bone[ J] .OsteoporosInt , 1997.7:S29.[ 6] Kuiper GGJM , Carlsson B ,Grandien K.Comparison of the ligandbinding specifi city and t ranscript tissue dist ribut ion of est rogenreceptorsαand β[ J] .Endocr inology , 1997 , 138:863.[ 7] Wei H , Bowen R , Cai Q , et al.Antioxidant and antipromot ionalef fects of the soybean isof lavone genistein[ J] .Proc Soc Exp BiolMed , 1995 , 208:124.[ 8] Markow itz SD , Robert s AB.Tumor suppressor activity of theTGF-β pathway in human cancers[ J] .Cytokine Growth FactorRev , 1997 , 7:93.[ 9] Constantinnou A , Kiguchi K ,Huberman E.Induct ion of diff eren-t iation and DNA st rand breakage in human HL-60 and K-562leukemia cells by genistein[ J] .Cancer Res , 1990 , 50:2618.[ 10] Thorburn J , Thorburn T.The tyrosine kinase inhibitor , genistein ,preventsα-adrenergic-induced cardiac muscel cell hypert rophy byinhibit ing act ivation of the Ras-MAP kinase signaling pathway[ J] .Biochem Biophys Res Commun , 1994 , 2002:1586.[ 11] Kim H , Peterson TG , Barnes S.Mechanisms of act ion of the soyisoflavone genistein:emerging role for it s ef fect s via t ransforminggrowth factor β signaling pathways[ J] .Am J Clin Nutr , 1998 ,68:1418S.[ 12] Wu AH , Ziegler RG , Horn-Ross PL , Tofu and risk of breast can-cer in Asian-Americans[ J] .Cancer Ep idemiol Biomarkers Prev ,1996 , 5:901.[ 13] Messina MJ.Legumes and soybeans:overview of their nut rit ionalprofiles and health effects[ J] .Am J Cl in Nutr , 1999 , 70:4395.[ 14] Arjmandi BH , Alekel L , Hollis BW.Dietary soybean protein pre-vents bone loss in an overiectomized rat model of osteoporosi s[ J] .J Nutr , 1996 , 126:161.[ 15] Potter SM , Baum JA , Teng H , et al.Soy protein and isof lavone;thei r ef fects on blood lipids and bone density in postmennopausalw omen[ J] .Am J Cl in Nutr , 1998 , 68(Suppl):1375S.[ 16] Nestel PJ , Yamashita T , Sasahara T , et al.S oyisofavones improvesystemic arterial compliance but not plasma lipids in memopausaland perimenopausal w omen[ J] .Arterioscler Thromb Vasc Biol ,1997 , 17:3392.[ 17] Honjo H , Kikuchi N , Hosoda T , et al.Alzheimers disease and es-trogen[ J] .J S teroid Biochem Mol Biol , 2001 , 76:227.[ 18] Dulzen DE , McDermot t JL.Gender di ff erences in neurotoxicity ofthe nigrostriatal dopaminergic system:implicat ions for Parkinso' sdisease[ J] .J Gend Specif Med , 2000 , 3:36.[ 19] White LR.Pet rovitch H , RossGW , et al.BrainAging and midlifetofu consumpt ion[ J] .J Am Coll Nutr , 2000 , 19:242.[ 20] Trieu VN , Uckun FM.Genistein is neuroprotect ive in mu rinemodels of fami lial amyot rophic lateral sclerosis and st roke[ J] .Biochem B iophys Res Comm um , 1999 , 258:685.[ 21] Ho KP , Li L , Qian ZM , et al.Genistein p rotect s primary corticalneuvous f rom iron-induced lipid peroxidation [ J] .Mol Cel lB iochem , 2002 , in press.[ 22] Qian ZM ,Wang Q.Expression of iron t ransport p roteins and ex-cessive iron accumulation in brain in neu rodegenerative disorders[ J] .Brain Res Rev , 1998 , 27:257.[ 23] Qian ZM , Shen X.Brain i ron transport and neurodegeneration[ J] .Trend Mol Med , 2001 , 7:91.[ 24] Ruiz-Larrea M ,M ohan A , Paganga G , et al.Antioxidant activityof phytoest rogenic isoflavones[ J] .F ree Radic Res , 1997 , 26:63.[ 25] Wiseman H ,O' Reilly JD , Adlercreutz H , et al.Isofavone phytoe-st rogens consumed in soy decrease F2-isoprostane concent rationsand increase resistance of low-density lipoprotein to oxidat ion inhumans[ J] .Am J Clin Nutr , 2000 , 72:395.(????:2002-03-05)药物肠道吸收的生物学研究方法李高 ,方超(???????????????? ,?? ?? 430030)????:?? Tel:(027)83692892??:??　介绍目前药物肠道吸收的生物学方法。??　对国内外有代表性的论文进行分析 、整理和归纳。??　综述了研究药物肠道吸收的生物学方法的基本操作步骤 、要领和特点。??　正确选用合适的研究方法 ,综合实验结果和模型特点·726· Chin Pharm J , 2002 October , Vol.37 No.10 　　　　　　　　　　　　 ?????? 2002? 10?? 37?? 10?

大豆异黄酮的药理作用和保健功能的研究进展

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