The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement

Abstract

Both genetics and biochemistry are used to demonstrate that the Ndc80 complex uses a tripartite attachment site to bind microtubules both in vitro and in vivo. Working together, the calponin homology domain and unstructured tail of Hec1 build a coupler that can move along the lateral surface of a depolymerizing microtubule