The authors are grateful to the Foundation for Science and
Technology (FCT, Portugal) for financial support through national
funds FCT/MCTES to CIMO (UIDB/00690/2020). L. Barros and R. C.
Calhelha thank the national funding by the FCT, P.I., through the institutional
scientific employment program-contract for their contracts.
M. Carocho also thanks the project ValorNatural for his research contract.
The authors are also grateful to the FEDER-Interreg España-
Portugal programme for financial support through the project
0377_Iberphenol_6_E.info:eu-repo/semantics/publishedVersio

Abreu, Rui M.V.

Alves, Maria José

Bachari, Khaldoun

Barros, Lillian

Calhelha, Ricardo C.

Carocho, Márcio

Ferreira, Isabel C.F.R.

Talhi, Oualid

Ziani, Borhane E.C.

Food Bioscience

To evaluate the phenolic profile and biological activity of the Algerian Sahara plant Acacia tortilis (Forssk.)
Hayne ssp. raddiana decoction and 80% ethanolic extracts were studied. Chromatographic profiling indicated
the presence of 36 phenolic compounds, including gallic acid esterified derivatives, galloylquinic derivatives and
flavan-3-ols galloyl derivatives. Both extracts showed significant cytotoxic activity and a potent anti-inflammatory
activity. They were effective against several multi-drug resistant bacteria, namely methicillin-resistant
Staphylococcus aureus (MRSA). To understand the possible mechanism of action of MRSA inhibition activity,
an in silico docking analysis was done using a virtual library of the 36 determined phenolic compounds
against penicillin-binding protein (PBP2a), a protein known to be involved in MRSA resistance to β-lactam
antibiotics. A. tortilis extracts showed interesting biological activities and the phenolic compounds found could
be an interesting starting point for the development of cytotoxic and anti-inflammatory drugs and especially
anti-MRSA antibiotics.The authors are grateful to the Foundation for Science and
Technology (FCT, Portugal) for financial support through national
funds FCT/MCTES to CIMO (UIDB/00690/2020). L. Barros and R. C.
Calhelha thank the national funding by the FCT, P.I., through the institutional
scientific employment program-contract for their contracts.
M. Carocho also thanks the project ValorNatural for his research contract.
The authors are also grateful to the FEDER-Interreg España-
Portugal programme for financial support through the project
0377_Iberphenol_6_E.info:eu-repo/semantics/publishedVersio

Biblioteca Digital do IPB

Phenolic profiling, biological activities and in silico studies of Acacia tortilis (Forssk.) Hayne ssp. raddiana extracts

http://bibliotecadigital.ipb.pt/bitstream/10198/16706/3/Engineering%20of%20Next.pdf

Phenolic profiling, biological activities and in silico studies of Acacia tortilis (Forssk.) Hayne ssp. raddiana extracts

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