Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylthioethers in the thieno[3,2-b]pyridine séries. In 1st Symposium on Medicinal Chemistry. Braga
Several thienopyridines have already been described as inhibitors of cell proliferation using
human tumor cells[1,2], highlighting the interest of studying their antitumorpotential. ln this work,
we present the synthesis of di(hetero)arylthioethers 1a-fby SNAr of the 7-chloro thieno[3,2-
b]pyridine with amino or methoxy thiophenols in good to high yields, like presented in the scheme.Foundation for the Science and Technology (FCT- Portugal) for financial support through
the NMR Portuguese network (Bruker 400 Avance 111-Univ Minho). To FCT and FEDERCOMPETE/
QREN/EU for financial support through the research unities PEst-C/QUI/UI686/2011
and PEst-OE/AGR/UI0690/20 11 , the research project PTDC/QUI-QUI/111 060/2009 and the postOoctoral
grant attributed to R.C.C. (SFRH/BPD/68344/2010) also financed by POPH and FSE
