The main goal of this review is to describe gametogenesis epigenetic erasure mechanisms and to propose candidate molecules which can erase remaining epigenetic marks that enhace re-differentiation of cultured induced pluripotent stem cells (iPSCs) into their tissue of origin. For accomplishing this objective, the most representative epigenetic events occurring during gametogenesis are detailed, because those are responsible for erasing parental epigenetic marks. Moreover, early embryonic development is also studied for describing pluripotency establishment. Finally, different epigenetic regulators from the three studied mechanisms are proposed as candidates to improve iPSCs generation protocols
