A Orlandi

Aki Mitsuda

AL Folpe

Atsushi Namiki

E Oliva

F Roncaroli

FJ Leong

G Falconieri

G Shanmugam

G Yorulmaz

Junichi Yamazaki

K Miyajima

Kanako Kitahara

Kazuhisa Takamura

Kazutoshi Shibuya

L Guillou

M Shintaku

Megumi Wakayama

Minoru Shinozaki

Nobuyuki Hiruta

Noriaki Kameda

PG Chu

PH Levine

S Kabir

S Neragi-Miandoab

SW Weiss

T Nikaido

Takao Ishiwatari

Tetsuo Nemoto

Y Oda

Y Oshiro

Yoichiro Okubo

BMC Cancer

English

PubMed

Springer - Publisher Connector

Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin

Abstract
          
            Background
            Leiomyosarcoma occurring as a primary cardiac tumor has been known as an extremely rare condition. Previous studies of leiomyosarcoma with rhabdomyoblastic differentiation have conducted to those arisen from another site, and they indicated a poorer prognosis of this tumor.
          
          
            Case presentation
            A 69-year-old woman was referred to our hospital for an operation concerning umbilical hernia. Subsequent imaging examinations before an operation indicated the presence of primary cardiac malignant tumor due to its atypical shape. And then, it was surgically removed. Histopathologically, tumor cells consisted of two different types: spindle and polyhedral cells. Immunohistochemically, it is interesting to note that 2.1% of spindle cells and 23.1% of polyhedral cells showed positive reactivity for myogenin. Furthermore, we performed double-immunostaining for alpha-smooth muscle actin (SMA) and myogenin. The rates of alpha-SMA and myogenin double negative, alpha-SMA single positive, myogenin single positive, and alpha-SMA and myogenin double positive in spindle cells were estimated as 69.1%, 28.8%, 1.1% and 1.0%, respectively. In contrast, the rates in polyhedral cells were estimated as 76.9%, 0.0%, 23.1%, and 0.0%, respectively.
          
          
            Conclusion
            Our immunohistochemical evaluation suggested that rhabdomyoblastic differentiation in leiomyosarcoma might be generated not only by de novo generation from mesenchymal cells. To the best of our knowledge, this is the first case of primary cardiac leiomyosarcoma with partial rhabdomyoblastic differentiation.
          </jats:sec

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3055234

Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin

Abstract

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