The asymmetric unit of the title compound, (C4H6N3O)2[InCl5(H2O)], comprises two independent cytosinium cations and an aquapentachloridoindate anion. The InIII ion is in a slightly distorted octahedral coordination geometry. In the crystal, alternating layers of cations and anions are arranged along [010] and are linked via intermolecular N—H⋯O, O—H⋯Cl and N—H⋯Cl hydrogen bonds, forming sheets parallel to (001). Additional stabilization within these sheeets is provided by weak intermolecular C—H⋯O interactions