Gonzalez-Gay, Miguel A

Gonzalez-Juanatey, Carlos

Llorca, Javier

Martin, Javier

Miranda-Filloy, Jose A

Arthritis Research & Therapy

English

PubMed

Miguel A Gonzalez-Gay

Carlos Gonzalez-Juanatey

Jose A Miranda-Filloy

Javier Martin

Javier Llorca

Crossref

Role of carotid ultrasonography in the evaluation of cardiovascular risk in patients with rheumatoid arthritis

González-Gay Mantecón, Miguel Ángel

González Juanatey, Carlos

Miranda Filloy, José Alberto

Martín Ibáñez, Javier

Llorca Díaz, Javier

UCrea

We read with great interest the article by Södergren and colleagues in a recent issue of Arthritis Research & Th erapy (‘Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thickness’) [1]. In the study reported in the article, the authors showed no diff erences of carotid artery intima-media thickness (IMT) in patients with very early rheumatoid arthritis (RA) compared with controls at baseline [1]. However, in the subgroup of individuals who were re-evaluated 18 months after the fi rst ultrasound measurement, the carotid IMT had increased signifi cantly among the patients with RA. However, this was not the case for the controls [1].With respect to these interesting observations, we would like to further emphasize the importance of carotid ultrasonography in the evaluation of the cardio-vascular risk of patients with RA and the importance of the duration of the disease as a predictor of severity, so it can infl uence the development of cardiovascular events in these patients. We previously reported that, in long-standing RA patients with no classic cardiovascular risk factors at the time of the carotid assessment, the duration of the disease was the best predictor of carotid plaques [2]. On the other hand, RA is a chronic infl ammatory disease, and even in the apparently quiescent phases of the disease, the cumulative eff ect of the chronic infl am-matory burden may account for the progression of the atherosclerosis disease. In this regard, we observed that the mean values of C-reactive protein (CRP) over an extended follow-up rather than a single determination of CRP at the time of the carotid ultrasonography evaluation were associated with the carotid IMT [3]. Moreover, we found that carotid artery IMT had a high predictive power for the development of cardiovascular events over a 5-year follow-up period in 47 patients with RA without clinically evident cardiovascular disease at the time of the carotid ultrasonography evaluation [4]. In our study, carotid IMT categorized in quartiles was strongly asso ciated with the development of cardiovascular events [4]. When logistic regression models were performed, carotid IMT at the time of the ultrasonographic study yielded a high predictive power for the development of cardio vascular events over the 5-year follow-up period. On the other hand, the duration of the disease is also considered an important risk factor of future cardio vascular events [5].Taking all of these considerations together, we propose that ultrasonographic assessment of the carotid artery be performed on all patients with RA in order to establish a subgroup of patients with a high risk of cardiovascular complications. Th is procedure should be carried out at the time of the disease diagnosis and periodically there-after, in particular in those patients with severe disease and persistent elevation of markers of infl ammation.AbbreviationsCRP, C-reactive protein; IMT, intima-media thickness; RA, rheumatoid arthritis.Competing interestsThe authors declare that they have no competing interests.Author details1Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Avda. Valdecilla, 39008-Santander, Spain. 2Division of Cardiology, Hospital Xeral-Calde, Rua Dr. Ochoa s/n, 27004-Lugo, Spain. 3Division of Rheumatology, Hospital Xeral-Calde, Rua Dr. Ochoa s/n, 27004-Lugo, Spain. 4Consejo Superior de Investigaciones Cientifi cas, Avda. del conocimiento s/n, 18100 Armilla (Granada), Spain. 5Division of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Avda. Herrera Oria s/n, 39011-Santander, Spain. 6CIBER Epidemiología y Salud Pública (CIBERESP), IFIMAV, Spain.Published: 16 December 2010© 2010 BioMed Central LtdRole of carotid ultrasonography in the evaluation of cardiovascular risk in patients with rheumatoid arthritisMiguel A Gonzalez-Gay†1, Carlos Gonzalez-Juanatey2, Jose A Miranda-Filloy3, Javier Martin4 and Javier Llorca*,†5,6See related research by Södergren et al., http://arthritis-research.com/content/12/4/R158L E T T E R†MAG-G and JL share senior authorship.*Correspondence: llorcaj@unican.es5Division of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Avda. Herrera Oria s/n, 39011-Santander, Spain.Full list of author information is available at the end of the articleGonzalez-Gay et al. Arthritis Research & Therapy 2010, 12:409 http://arthritis-research.com/content/12/6/409© 2010 BioMed Central LtdReferences1. Södergren A, Karp K, Boman K, Eriksson C, Lundström E, Smedby T, Söderlund L, Rantapää-Dahlqvist S, Wållberg-Jonsson S: Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thickness. Arthritis Res Ther 2010, 12:R158.2. Gonzalez-Juanatey C, Llorca J, Testa A, Revuelta J, Garcia-Porrua C, Gonzalez-Gay MA: Increased prevalence of severe subclinical atherosclerotic fi ndings in long-term treated rheumatoid arthritis patients without clinically evident atherosclerotic disease. Medicine (Baltimore) 2003, 82:407-413.3. Gonzalez-Gay MA, Gonzalez-Juanatey C, Piñeiro A, Garcia-Porrua C, Testa A, Llorca J: High-grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis. J Rheumatol 2005, 32:1219-1223.4. Gonzalez-Juanatey C, Llorca J, Martin J, Gonzalez-Gay MA: Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis. Semin Arthritis Rheum 2009, 38:366-371.5. Peters MJ, Symmons DP, McCarey D, Dijkmans BA, Nicola P, Kvien TK, McInnes IB, Haentzschel H, Gonzalez-Gay MA, Provan S, Semb A, Sidiropoulos P, Kitas G, Smulders YM, Soubrier M, Szekanecz Z, Sattar N, Nurmohamed MT: EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of infl ammatory arthritis. Ann Rheum Dis 2010, 69:325-331.doi:10.1186/ar3186Cite this article as: Gonzalez-Gay MA, et al.: Role of carotid ultrasonography in the evaluation of cardiovascular risk in patients with rheumatoid arthritis. Arthritis Research & Therapy 2010, 12:409.Gonzalez-Gay et al. Arthritis Research & Therapy 2010, 12:409 http://arthritis-research.com/content/12/6/409Page 2 of 2

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Role of carotid ultrasonography in the evaluation of cardiovascular risk in patients with rheumatoid arthritis

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