This virus is distinct from rabbit hemorrhagic disease virus

Altschul

Annabel G. Wise

Asgari

Capucci

Chasey

Ferreira

Forrester

Garcia

Green

Ingrid L. Bergin

Löliger

Martin-Alonso

Matti Kiupel

McIntosh

Ohlinger

Prieto

Roger K. Maes

Steven R. Bolin

Teifke

Thomas P. Mullaney

White

Emerging Infectious Diseases

English

PubMed

We report a disease outbreak in a Michigan rabbitry of a rabbit calicivirus distinct from the foreign animal disease agent, rabbit hemorrhagic disease virus (RHDV). The novel virus has been designated Michigan rabbit calicivirus (MRCV). Caliciviruses of the Lagovirus genus other than RHDV have not been described in US rabbit populations. The case-fatality rate was 32.5% (65/200). Clinical signs included hemorrhage and sudden death, with hepatic necrosis. Analysis of viral RNA sequence from >95% of the viral genome showed an average similarity of 79% with RHDV. Similarity of the predicted MRCV capsid amino acid sequence ranged from 89.8% to 91.3%, much lower than the 98% amino acid similarity between RHDV strains. Experimentally infected rabbits lacked clinical disease, but MRCV was detected in tissues by PCR. We propose that MRCV primarily causes subclinical infection but may induce overt RHD-like disease under certain field conditions

Directory of Open Access Journals

Novel Calicivirus Identified in Rabbits, Michigan, USA

Crossref

A new viral disease of rabbits [in Chinese]. Anim Husband Vet Med.

A pandemic strain of calicivirus threatens rabbit industries in the Americas. Virol J.

Adult rabbits acquire resistance to lethal calicivirus infection by adoptive transfer of sera from infected young rabbits. Vet Immunol Immunopathol.

and control of viral hemorrhagic disease of rabbits and the European brown hare syndrome virus in Germany. Rev Sci Tech.

Animal Health Association. Foreign animal diseases, 7th ed.

Basic local alignment search tool.

Benign circulation of rabbit hemorrhagic disease virus on Lambay Island,

Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease but nonpathogenic.

Epidemiology of rabbit hemorrhagic disease virus in the United Kingdom: evidence for seasonal transmission by both virulent and avirulent modes of infection.

et al Immunohistochemical localization of rabbit hemorrhagic disease virus VP-60 antigen in early infection of young and adult rabbits. Res Vet Sci.

Identiﬁ cation and characterization of the virus causing rabbit hemorrhagic disease.

Isolation and characterization of a new Vesivirus from rabbits.

Liver disease in young rabbits infected by calicivirus through nasal and oral routes. Res Vet Sci.

Porcine circovirus type 2 (PCV2) causes apoptosis in experimentally inoculated BALB/c mice. BMC Vet Res.

Rabbit haemorrhagic disease: the new scourge of Oryctolagus cuniculus. Lab Anim.

Sequence analysis of rabbit hemorrhagic disease virus (RHDV) in Australia: alterations after its release. Arch Virol.

Seroconversion in an industrial unit of rabbits infected with a non-pathogenic rabbit hemorrhagic disease-like virus. Vet Rec.

Subacute liver necrosis after experimental infection with rabbit hemorrhagic disease virus.

Taxonomy of the caliciviruses. J Infect Dis. 2000;181(Suppl 2):S322–30.

The rabbit as a new reservoir host of enterohemorrhagic Escherichia coli. Emerg Infect Dis.

Transient decrease in blood heterophils and sustained liver damage caused by calicivirus infection of young rabbits that are naturally resistant to rabbit hemorrhagic disease. Res Vet Sci.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3044539

Novel Calicivirus Identified in Rabbits, Michigan, USA

Abstract

Similar works

Full text

Available Versions

Directory of Open Access Journals

Crossref