Using their experiences from, and analysis of, global campaigns to eradicate smallpox, poliomyelitis, and measles, Myron Levine and colleagues derive lessons for malaria eradication

A Hinman

A Tischer

AR Bruce

AS Jegede

AW Rimoin

BA Rubin

C Daneshvar

CA De Quadros

Ciro A. de Quadros

CT Bauch

DB Thomas

DJ Sencer

Donald A. Henderson

EK Szusz

F Fenner

FL Black

FL Ruben

H Whittle

I Arita

ID Ladnyj

J Gindler

JD Sparkes

JG Breman

JH Nakano

JK Simon

Joel G. Breman

K Hughes

KM Van Buskirk

KR Dumbell

LW Rauh

M Tapia

ME Ramsay

MF Pasetti

MN Mulders

Myron M. Levine

N Khetsuriani

N Nathanson

O Kew

OM Kew

PA Patriarca

PM Strebel

R Obregon

R Sutter

RB Aylward

RF Grais

RH Henderson

RJ Baptista Jr

RJ Tebbens

RN Basu

RR Roberto

S Conteh

S Crotty

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SB Omer

SL Hoffman

T Duke

T. Jacob John

TJ John

TM Mack

V Takpa

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W Dowdle

W Pongtavornpinyo

Walter R. Dowdle

WH Foege

William H. Foege

WJ Bellini

WR Taylor

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Z Jezek

PLoS Medicine

English

PubMed

Breman Joel G.

de Quadros Ciro A.

Dowdle Walter R.

Foege William H.

Henderson Donald A.

John T. Jacob

Levine Myron M.

Public Library of Science (PLOS)

The Role of Research in Viral Disease Eradication and Elimination Programs: Lessons for Malaria Eradication

By examining the role research has played in eradication or regional elimination initiatives for three viral diseases--smallpox, poliomyelitis, and measles--we derive nine cross-cutting lessons applicable to malaria eradication. In these initiatives, some types of research commenced as the programs began and proceeded in parallel. Basic laboratory, clinical, and field research all contributed notably to progress made in the viral programs. For each program, vaccine was the lynchpin intervention, but as the programs progressed, research was required to improve vaccine formulations, delivery methods, and immunization schedules. Surveillance was fundamental to all three programs, whilst polio eradication also required improved diagnostic methods to identify asymptomatic infections. Molecular characterization of pathogen isolates strengthened surveillance and allowed insights into the geographic source of infections and their spread. Anthropologic, sociologic, and behavioural research were needed to address cultural and religious beliefs to expand community acceptance. The last phases of elimination and eradication became increasingly difficult, as a nil incidence was approached. Any eradication initiative for malaria must incorporate flexible research agendas that can adapt to changing epidemiologic contingencies and allow planning for posteradication scenarios

Joel G Breman

Ciro A de Quadros

Walter R Dowdle

William H Foege

Donald A Henderson

T Jacob John

Myron M Levine

Directory of Open Access Journals

The role of research in viral disease eradication and elimination programs: lessons for malaria eradication.

By examining the role research has played in eradication or regional elimination initiatives for three viral diseases--smallpox, poliomyelitis, and measles--we derive nine cross-cutting lessons applicable to malaria eradication. In these initiatives, some types of research commenced as the programs began and proceeded in parallel. Basic laboratory, clinical, and field research all contributed notably to progress made in the viral programs. For each program, vaccine was the lynchpin intervention, but as the programs progressed, research was required to improve vaccine formulations, delivery methods, and immunization schedules. Surveillance was fundamental to all three programs, whilst polio eradication also required improved diagnostic methods to identify asymptomatic infections. Molecular characterization of pathogen isolates strengthened surveillance and allowed insights into the geographic source of infections and their spread. Anthropologic, sociologic, and behavioural research were needed to address cultural and religious beliefs to expand community acceptance. The last phases of elimination and eradication became increasingly difficult, as a nil incidence was approached. Any eradication initiative for malaria must incorporate flexible research agendas that can adapt to changing epidemiologic contingencies and allow planning for posteradication scenarios.\ud
\u

Breman, Joel G

de Quadros, Ciro A

Dowdle, Walter R

Foege, William H

Henderson, Donald A

John, T Jacob

Levine, Myron M

Name not available

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The Role of Research in Viral Disease Eradication and Elimination Programs: Lessons for Malaria Eradication

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