D. Tarullo

Dabelea

Giovannucci

Hokanson

J. E. Hokanson

J. K. Snell-Bergeon

K. A. Young

Krolewski

Libby

Littorin

M. Rewers

Michos

O'halloran

Olson

P. A. Gottlieb

Pozzilli

R. G. Naik

S. K. Garg

SCRAGG

Vieth

Zhou

English

PubMed


                  OBJECTIVE
                  The objective of this study is to examine the relationship among serum levels of 25-hydroxyvitamin D (25[OH]D), polymorphisms in vitamin D-associated genes, and the presence and progression of coronary artery calcification (CAC) in adults with type 1 diabetes.
               
               
                  RESEARCH DESIGN AND METHODS
                  This prospective study included 374 non-Hispanic white individuals with type 1 diabetes (mean age 40 ± 9 years; 46% were male). CAC was measured at the baseline and 3- and 6-year follow-up visits were determined by electron beam computed tomography. Serum 25[OH]D levels were measured by liquid chromatography tandem mass spectrometry at the 3-year visit.
               
               
                  RESULTS
                  Normal (&amp;gt;30 ng/mL), insufficient (20–30 ng/mL), and deficient (&amp;lt;20 ng/mL) 25-[OH]D levels were present in 65%, 25%, and 10% of the individuals with type 1 diabetes, respectively. 25[OH]D deficiency was associated with the presence of CAC at the 3-year visit, odds ratio (OR) = 3.3 (95% CI 1.6–7.0), adjusting for age, sex, and hours of daylight. In subjects free of CAC at the 3-year visit, 25[OH]D deficiency predicted the development of CAC over the next 3 years in those with the vitamin D receptor M1T CC genotype (OR = 6.5 [1.1–40.2], P = 0.04) than in those with the CT or TT genotype (OR = 1.6 [0.3–8.6], P = 0.57).
               
               
                  CONCLUSIONS
                  Vitamin D deficiency independently predicts prevalence and development of CAC, a marker of coronary artery plaque burden, in individuals with type 1 diabetes.
               </jats:sec

Kendra A. Young

Janet K. Snell-Bergeon

Ramachandra G. Naik

John E. Hokanson

David Tarullo

Peter A. Gottlieb

Satish K. Garg

Marian Rewers

Crossref

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Vitamin D Deficiency and Coronary Artery Calcification in Subjects With Type 1 Diabetes

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