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Phylogeny of Mycobacterium tuberculosis Beijing Strains Constructed from Polymorphisms in Genes Involved in DNA Replication, Recombination and Repair
Authors
AG Tsolaki
Alan Murray
+32 more
Amine Namouchi
Anil Kumar Tyagi
Brigitte Gicquel
Céline Jackson
D Van Soolingen
E Denamur
HJ Bandelt
I Filliol
JA Caminero
Jean Rauzier
Jian Mei
K Kremer
K Kremer
Kristin Kremer
L Baker
L Rindi
L Zhang
M Achtman
ME Rad
MM Gutacker
NJ Moreland
Olga Mestre
Pablo Bifani
PJ Bifani
Qian Gao
R Hershberg
Rob Warren
S Sreevatsan
T Dos Vultos
Tao Luo
Tiago Dos Vultos
Voahangy Rasolofo
Publication date
1 January 2011
Publisher
Public Library of Science
Doi
View
on
PubMed
Abstract
The original publication is available at http:/www.plosone.orgBackground: The Beijing family is a successful group of M. tuberculosis strains, often associated with drug resistance and widely distributed throughout the world. Polymorphic genetic markers have been used to type particular M. tuberculosis strains. We recently identified a group of polymorphic DNA repair replication and recombination (3R) genes. It was shown that evolution of M. tuberculosis complex strains can be studied using 3R SNPs and a high-resolution tool for strain discrimination was developed. Here we investigated the genetic diversity and propose a phylogeny for Beijing strains by analyzing polymorphisms in 3R genes. Methodology/Principal Findings: A group of 3R genes was sequenced in a collection of Beijing strains from different geographic origins. Sequence analysis and comparison with the ones of non-Beijing strains identified several SNPs. These SNPs were used to type a larger collection of Beijing strains and allowed identification of 26 different sequence types for which a phylogeny was constructed. Phylogenetic relationships established by sequence types were in agreement with evolutionary pathways suggested by other genetic markers, such as Large Sequence Polymorphisms (LSPs). A recent Beijing genotype (Bmyc10), which included 60% of strains from distinct parts of the world, appeared to be predominant. Conclusions/Significance: We found SNPs in 3R genes associated with the Beijing family, which enabled discrimination of different groups and the proposal of a phylogeny. The Beijing family can be divided into different groups characterized by particular genetic polymorphisms that may reflect pathogenic features. These SNPs are new, potential genetic markers that may contribute to better understand the success of the Beijing family. © 2011 Mestre et al.Publishers' Versio
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