A Frustaci

B Kwak

C Indolfi

D Amar

F Marin

G Mariscalco

G Patti

Heart Protection Study Collaborative Group

KK Ray

L Fauchier

M Gaudino

M Ozaydin

MI Dotani

MK Chung

N Echahidi

PM Ridker

PS Sever

R Patel

RO Bonow

S Oi

SF Su

SS Virani

TT Isaac

English

PubMed

R. J. Folkeringa

R. G. Tieleman

J. G. Maessen

M. H. Prins

R. Nieuwlaat

H. J. G. M. Crijns

Springer - Publisher Connector

Statins Do Not Reduce Atrial Fibrillation After Cardiac Valvular Surgery: A Single Centre Observational Study

Crossref

Netherlands Heart Journal

Introduction Statins may theoretically reduce postoperative atrial fibrillation (AF) in patients after cardiac valvular surgery due to preservation of endothelial function and anti-ischaemic, anti-inflammatory and anti-remodelling effects. Methods Two hundred seventy-two patients who underwent cardiac workup and subsequently cardiac valvular surgery without AF and concomitant coronary artery bypass grafting (CABG) at our hospital were selected. Preoperative drug use and postoperative AF were recorded. AF was defined as any episode of AF longer than 10 s. In addition, results from echocardiography and blood samples were retrieved. Results Baseline characteristics were as follows: mean age was 65 +/- 11 years, 142 (52%) patients were male, 189 (70%) had undergone aortic valve surgery and the mean left ventricular ejection fraction was 57 +/- 12%. Statins were used by 79 patients (29%). Statin users, more often, had a prior percutaneous coronary intervention (25% vs 9%, p <0.001) or CABG (24% vs 4%, p <0.001), diabetes mellitus (22% vs 5%, p <0.001) and more often used beta-blockers (51% vs 24%, 

Folkeringa, Johan R.

Tieleman, R. G.

Maessen, J. G.

Prins, M. H.

Nieuwlaat, R.

Crijns, H. J. G. M.

NARCIS 

Germans, T.

Nijveldt, R.

Brouwer, W.P

Groothuis, J.G.J.

Beek, A.M.

Gotte, M.J.W.

van Rossum, A.C.

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Statins Do Not Reduce Atrial Fibrillation After Cardiac Valvular Surgery: A Single Centre Observational Study

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