The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis

Abstract

This paper reveals a tumour-promoting function of the candidate tumour suppressor CCAAT/enhancer-binding protein-δ. Identification of F-box and WD repeat-domain containing 7 protein as CCAAT/enhancer-binding protein-δ target links hypoxic inflammation and tumour metastasis via mammalian target of rapamycin-mediated hypoxia-inducible factor-1α stabilization