Abdou, Biba

Boisier, Pascal

Boubacar, Halima

Tohon, Zilahatou

Yahaya, Ramatou

English

PubMed

Zilahatou Tohon

Halima Boubacar

Ramatou Yahaya

Biba Abdou

Pascal Boisier

Springer - Publisher Connector

Five years follow-up of schoolchildren infected with schistosomiasis in Niger: evidence of the benefit of a regular praziquantel administration on the reinfection

POSTER PRESENTATION Open Access
Five years follow-up of schoolchildren infected
with schistosomiasis in Niger: evidence of the
benefit of a regular praziquantel administration
on the reinfection
Zilahatou Tohon1*, Halima Boubacar1, Ramatou Yahaya1, Biba Abdou1, Pascal Boisier2
From Institut Pasteur International Network Annual Scientific Meeting
Hong Kong. 22-23 November 2010
Background
The WHO’s objective regarding schistosomiasis control
is to maintain a low burden by maintaining lower para-
sitic charges in endemic regions. The schistosomiasis
and helminthiasis control program was launched in
2004 in Niger. Although yearly praziquantel treatment
does not clear entirely schistosomiasis worms in people,
it allows reducing parasitic loads and thus avoids serious
renal complications. A study was carried out to estimate
the annual prevalence of Schistosoma haematobium
infection and its related morbidity among schoolchildren
living in 5 endemic villages between 2004 and 2009.
Results
A longitudinal follow-up of school age children was
undertaken with pre-treatment examination and follow-
up each year prior to mass drug administration cam-
paign. Prevalence of schistosomiasis and anaemia was
assessed through interview, urine examination, ultra-
sound of the kidney and urinary tract, and measurement
of haemoglobin. At baseline, S. haematobium infection
prevalence was 76.8% among the 1017 enrolled school-
children. Among the infected, 30.2% excreted more than
50 eggs/10 ml of urine. After 4 and 5 years of follow-up,
urinary schistosomiasis was respectively retrieved among
44.3% and 26.5% of the 680 and 581 children, respec-
tively. A proportion of 23.0% of uninfected schoolchil-
dren at baseline became infected at year 4. Conversely,
48% of schoolchildren with positive egg count at base-
line were found negative at year 4 (p<0.001). These
results remained significant taking into account the vil-
lage. At baseline, anaemia was present in 63.1% of chil-
dren, and its prevalence significantly decreases with
increasing age. This prevalence was reduced to 51.8%,
40.5% and 25.9% at years 2, 3 and 5 of follow-up
respectively.
Conclusion
The prevalence of ultrasound bladder abnormalities was
37.7% at baseline and this prevalence dropped to 2.6%
at year 5 of follow-up. Regular praziquantel treatment
had positive impact on the prevalence of schistosomiasis
as well as on its intensity and on the reinfection rate.
These results encourage proceeding with the national
schistosomiasis and geohelminthiasis control
programme.
Author details
1Unité d’Epidémiologie, Centre de Recherche Médicale et Sanitaire, BP 10887
Niamey, Niger. 2Laboratoire d’Epidémiologie, Centre Pasteur du Cameroun,
BP 1274, Yaoundé, Cameroun.
Published: 10 January 2011
doi:10.1186/1753-6561-5-S1-P57
Cite this article as: Tohon et al.: Five years follow-up of schoolchildren
infected with schistosomiasis in Niger: evidence of the benefit of a
regular praziquantel administration on the reinfection. BMC Proceedings
2011 5(Suppl 1):P57.
1Unité d’Epidémiologie, Centre de Recherche Médicale et Sanitaire, BP 10887
Niamey, Niger
Full list of author information is available at the end of the article
Tohon et al. BMC Proceedings 2011, 5(Suppl 1):P57
http://www.biomedcentral.com/1753-6561/5/S1/P57
© 2011 Tohon et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.


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Five years follow-up of schoolchildren infected with schistosomiasis in Niger: evidence of the benefit of a regular praziquantel administration on the reinfection

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