The asymmetric unit of the title compound, C22H27FN2O2, a (−)-S-meptazinol derivative, contains two molecules. The azepane ring adopts a similar twist chair form in both molecules, while the dihedral angles between the two benzene rings are 88.17 (14) and 89.93 (14)° in the two molecules. The absolute configuration of the molecule was determined from the synthetic starting material. The crystal structure is stabilized by classical intermolecular N—H⋯O hydrogen bonds
