TIA-1 Cytotoxic Granule-Associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-Proficient Colorectal Cancer

A Sasaki; Alessandro Lugli; Alexandar Tzankov; Alfons Navarro; AR Dadabayev; B Chetaille; C Compton; CA Rubio; DM Frey; DP O'Malley; E Steyerberg; EM de Kruijf; Eva Karamitopoulou; F Pages; Giandomenica Iezzi; Giulio Spagnoli; H Suzuki; Inti Zlobec; J Galon; J Shetye; JM Izquierdo; JR Jass; K Baker; K Baker; Kristi Baker; L Goethals; Luigi Terracciano; M Camus; M Santucci; MA Jenkins; Manuele Giuseppe Muraro; N Chaput; OJ Finn; P Forch; P Royston; P Salama; R Dolcetti; RP Carroll; S Mallett; S Mocellin; S Popat; Salvatore Piscuoglio; T Alvaro; TV Perneger

TIA-1 Cytotoxic Granule-Associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-Proficient Colorectal Cancer

Authors: A Sasaki
Alessandro Lugli
Alexandar Tzankov
Alfons Navarro
AR Dadabayev
B Chetaille
C Compton
CA Rubio
DM Frey
DP O'Malley
E Steyerberg
EM de Kruijf
Eva Karamitopoulou
F Pages
Giandomenica Iezzi
Giulio Spagnoli
H Suzuki
Inti Zlobec
J Galon
J Shetye
JM Izquierdo
JR Jass
K Baker
K Baker
Kristi Baker
L Goethals
Luigi Terracciano
M Camus
M Santucci
MA Jenkins
Manuele Giuseppe Muraro
N Chaput
OJ Finn
P Forch
P Royston
P Salama
R Dolcetti
RP Carroll
S Mallett
S Mocellin
S Popat
Salvatore Piscuoglio
T Alvaro
TV Perneger
Publication date: 1 January 2010
Publisher: Public Library of Science
Doi

Abstract

Evidence suggests a confounding effect of mismatch repair (MMR) status on immune response in colorectal cancer. The identification of innate and adaptive immune cells, that can complement the established prognostic effect of CD8 in MMR-proficient colorectal cancers patients, representing 85% of all cases, has not been performed