'American Society for Biochemistry & Molecular Biology (ASBMB)'
Abstract
The deoxyribonucleases1 of animal tissues are of two types which are readily distinguishable by the conditions necessary for activity on their substrate, DNA. The pancreatic DNase, which has been crystallized by Kunitz (1), is active in neutral solution in the presence of magnesium or certain other divalent cations (2). The DN ase predominant in most other tissues is active at a lower pH, in the presence of adequate ionic strength, but does not specifically require divalent ions
