DJ Müller

L Mandelli

Laura Mandelli

Annals of General Psychiatry

English

PubMed

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MEETING ABSTRACT Open Access
Insights from pharmacogenetic studies of
antidepressants
Laura Mandelli
From 1st International Congress on Neurobiology and Clinical Psychopharmacology and European
Psychiatric Association Conference on Treatment Guidance
Thessaloniki, Greece. 19-22 November 2009
Up to 60% of depressed patients do not respond comple-
tely to antidepressants and up to 30% do not respond at
all. Among the many reasons leading to non-response,
such as inadequate treatments and comorbid conditions,
genetic factors as likely to contribute to up to 50% of var-
iance in antidepressant response. Environmental factors,
such as chronic stressors, psychosocial adjustment and
personality traits may also influence response to treat-
ment and interact with these. The investigation of both
of these types of factors has been informative in genetic
aetiological studies (e.g. Caspi et al., 2003) and is increas-
ingly employed in pharmacogenetics.
A growing number of genetic variants have been repli-
cated in terms of association with SSRI efficacy. They
include polymorphisms in the serotonin transporter gene
(5-HTTLPR), tryptophan hydroxylase gene (TPH),
5HT1A and 5HT2A receptors, the G-protein beta3-
subunit (GNB3), Catechol-O-methyltransferase (COMT),
the noradrenaline transporter (NAT), and dystrobrevin
binding protein 1 (DTNBP1). Data indicating environ-
mental stressors and temperamental traits as moderators
of the effect of such genes on response to treatment will
also be presented.
In conclusion, there are genetic and environmental
factors that interact in a complex manner to impact on
response to treatment with antidepressants. Increased
understanding of these, including clinical characteristics
such as “harm avoidance,” may assist the clinician in
deciding the best antidepressant to prescribe for a given
patient.
Published: 22 April 2010
References
1. Mandelli L, Mazza M, Martinotti G, et al: Harm avoidance moderates the
influence of serotonin transporter gene variants on treatment outcome
in bipolar patients. J Affect Disord .
2. Mandelli L, Marino E, Pirovano A, Calati R, et al: Interaction between
SERTPR and stressful life events on response to antidepressant
treatment. Eur Neuropsychopharmacol 2009.
3. Mandelli L, Serretti A, Marino E, et al: Interaction between serotonin
transporter gene, catechol-O-methyltransferase gene and stressful life
events in mood disorders. Int J Neuropsychopharmacol 2007, 10(4):437-47.
4. Müller DJ, Mandelli L, Serretti A, et al: Serotonin transporter gene and
adverse life events in adult ADHD. Am J Med Genet B Neuropsychiatr Genet
2008, 147B(8):1461-9.
doi:10.1186/1744-859X-9-S1-S8
Cite this article as: Mandelli: Insights from pharmacogenetic studies of
antidepressants. Annals of General Psychiatry 2010 9(Suppl 1):S8.
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Institute of Psychiatry, University of Bologna, Italy
Mandelli Annals of General Psychiatry 2010, 9(Suppl 1):S8
http://www.annals-general-psychiatry.com/content/9/S1/S8
© 2009 Mandelli; licensee BioMed Central Ltd.


Insights from pharmacogenetic studies of antidepressants

Crossref

al: Serotonin transporter gene and adverse life events in adult ADHD.

et al: Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders.

et al: Interaction between SERTPR and stressful life events on response to antidepressant treatment. Eur Neuropsychopharmacol

Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance

https://annals-general-psychiatry.biomedcentral.com/track/pdf/10.1186/1744-859X-9-S1-S8?site=annals-general-psychiatry.biomedcentral.com

Insights from pharmacogenetic studies of antidepressants

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