Benito-Lopez, Fernando

Diamond, Dermot

Florea, Larisa

Saez, Janire

Tudor, Alexandru

Name not available

TEMPERATURE-CONTROLLED  POLY(IONIC LIQUID) MICROFLUIDIC VALVES Introduction Alexandru Tudor†a, Janire Saez†b, Larisa Florea*a, Fernando Benito-Lopez*b and Dermot Diamonda PIL Hydrogel Synthesis The authors are grateful for financial support from the Marie Curie Initial Training Network funded by the EC FP7 People Programme OrgBIO (Marie Curie ITN, GA607896), Science Foundation Ireland (SFI) under the Insight Centre for Data Analytics initiative, Grant Number SFI/12/RC/2289, and to the Ramón y Cajal Programme (Ministerio de Economía y Competitividad). PSPA Photoinitiator H2O + Acetonitrile 5 mol % PPG800 3 mm  1 mm  ~200 kLux for 30min  a Dublin City University, Insight Centre for Data Analytics, National Centre for Sensor Research, Dublin, Ireland b University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain Temperature – Induced Shrinking Conclusion Acknowledgements Tributylhexyl phosphonium  3-sulfopropyl acrylate (PSPA)  Poly(propylene glycol) diacrylate (PPG800)  Microfluidic Chip Design The increase in temperature from 20 °C to 50 °C causes the hydrogels to shrink by ~ 44 % (± 3 %, n = 6) and revert back to ~ 97 % (± 2 %, n = 6) of their original size when the temperature is lowered to 20 °C. Poly(ionic liquid)s (PILs) are ionic liquids that feature polymerizable groups either in the cation, the anion or both. Applications of these materials include solid ion conductors, CO2 absorption and energy storage. Furthermore, a branch of PILs feature lower critical solution temperature (LCST) behaviour, making them suitable for the synthesis of temperature responsive materials. The aim of this study was to synthesize thermo-responsive crosslinked PIL hydrogels based on phosphonium PILs and embed them in microfluidic devices to be used as temperature controlled valves. The microfluidic chip consists of three layers of poly(methyl methacrylate) bound with two layers of pressure sensitive adhesive (PSA). The channel was made in the PSA layer (~250 μm). The device has a total thickness of 1 mm. PSPA crosslinked hydrogels where synthesized and had their temperature-response quantified. Following this, they were embedded in microfluidic devices as temperature controlled valves. The analysis showed that they can modulate the flow of deionized water through the chip when the temperature was cycled between 20 °C and 50 °C.  Inlet Outlet Gel Chamber Channel From 20 °C to 70 °C Top view Side view 0204060801001201401600.00 5.00 10.00 15.00Flow (nL·min-1) Time (s) 0204060801001201400.00 5.00 10.00 15.00 20.00Flow (nL·min-1) Time (s) Bottom PMMA Layer First PSA Layer Polymer Well PMMA Layer Microfluidic channel PSA Layer Top PMMA Layer with Inlet and Outlet Flow Characterization Syringe Pump Chip Heater Nanoflow meter 500 nL·min-1 A flow microsensor was used to analyze the flow rate while the temperature was cycled between 20 °C and 50 °C. When the chip was heated to 50 °C, a flow of ~130 nL·min-1 was observed, while at 20 °C the flow rate dropped to ~30 nL·min-1.  Opening and closing time for the PILc hydrogel valve vary between 6s to 8s, which are particularly fast times for this type of valves.  

Temperature-controlled poly(ionic liquid) microfluidic valves

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Temperature-controlled poly(ionic liquid) microfluidic valves

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