Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115972/1/nbm3418.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/115972/2/nbm3418_am.pd

Aryal

Bagher-Ebadian

Bereczki

Blasberg

Boucher

Brown

Bruehlmeier

Ewing

Gelman

Hassid

Hompland

Jain

Levin

Logan

Ludemann

Magdoom

Munson

Nagaraja

Netti

Nield

Pathak

Patlak

Pishko

Pronin

R Core Team

Sarntinoranont

Scheffé

Sirianni

Sourbron

Stylianopoulos

Sykova

Tofts

Yankeelov

NMR in Biomedicine

English

PubMed

James R. Ewing

Tavarekere N. Nagaraja

Madhava P. Aryal

Kelly A. Keenan

Rasha Elmghirbi

Hassan Bagher-Ebadian

Swayamprava Panda

Mei Lu

Tom Mikkelsen

Glauber Cabral

Stephen L. Brown

Crossref

Peritumoral tissue compression is predictive of exudate flux in a rat model of cerebral tumor: an MRI study in an embedded tumor

Ewing, James R.

Nagaraja, Tavarekere N.

Aryal, Madhava P.

Keenan, Kelly A.

Elmghirbi, Rasha

Bagher‐ebadian, Hassan

Panda, Swayamprava

Lu, Mei

Mikkelsen, Tom

Cabral, Glauber

Brown, Stephen L.

Deep Blue Documents at the University of Michigan

MRI estimates of extracellular volume and tumor exudate flux in peritumoral tissue are demonstrated in an experimental model of cerebral tumor. Peritumoral extracellular volume predicted the tumor exudate flux. Eighteen RNU athymic rats were inoculated intracerebrally with U251MG tumor cells and studied with dynamic contrast enhanced MRI (DCE-MRI) approximately 18 days post implantation. Using a model selection paradigm and a novel application of Patlak and Logan plots to DCE-MRI data, the distribution volume (i.e. tissue porosity) in the leaky rim of the tumor and that in the tissue external to the rim (the outer rim) were estimated, as was the tumor exudate flow from the inner rim of the tumor through the outer rim. Distribution volume in the outer rim was approximately half that of the inner adjacent region (p \u3c 1 × 10(-4)). The distribution volume of the outer ring was significantly correlated (R(2) = 0.9) with tumor exudate flow from the inner rim. Thus, peritumoral extracellular volume predicted the rate of tumor exudate flux. One explanation for these data is that perfusion, i.e. the delivery of blood to the tumor, was regulated by the compression of the mostly normal tissue of the tumor rim, and that the tumor exudate flow was limited by tumor perfusion

Peritumoral tissue compression is predictive of exudate flux in a rat model of cerebral tumor: an MRI study in an embedded tumor

Abstract

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Deep Blue Documents at the University of Michigan

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