Forrester, Mathias B.

Merz, Ruth D.

eVols at University of Hawaii at Manoa

Cancer ResearchCenter HotlineDescription of Neoplasms in InfantsDiagnosed Under One Year of Agein Hawaii, 1986-2000Ruth D. Merz, MS, AdministratorMathias B. Forrester, BS, Data ConsultantHawaii Birth Defects ProgramCancer Research Center of Hawaii,University of Hawaii andHawaii State Department of HealthHawaii Birth Defects Program (HBDP)The I-faa an Birth Defects Program (HBDI’) was established inAugust 1 as a surveillance system and reeistrv for birth defectsand other adverse pregnancy outcomes,. \ birth defect is defined asan structural, functional, or biochemical abnormality in development that originates before birth and is detectable at birth or shortlythereafter, These defects may be genetically linked or caused byenvironniental hazards or adverse lifestyic eitècts, but most oftenare ol rinknoss n origin.’Birth detects are the single most common cause 01 tntant mortalityin Has’s ai I e’scept for other perinatal conditions and all other causes.—On average I .()0t) i5 of all babies born each ear in Hawaii arediagnosed a ith somc recognizable ads erse pregnancy outcome.About 12’ ( of all admissions to pediatric hospitals arc caused bypisblenis dircctlv associated a ith birth detects: As a result, birthdetects and other adverse pregnancy outcomes represent a signi fi—cant impact for Hawaii’s hospitals and hnni lies.The purpose ot the HBDP is to be a reliable, valid, and timelintormation oni’ce for asccrtainine the number of infants up to oneear ot age ss ith specilic birth dehcts and other ads crse reproductive outcomes, as a cli as providina reles ant and timcly informationand data to community agencies. hospitals. and state departments forpolic . planning. and decision making purposes. The HBDP worksto fulfill this objective by being a statess ide, population—basedsurveillance system that uses active ascertainment methodology andcollects intormation from multiple sources (approximately 33 healthcare facilities and vital records3With its 15 years of data and statistical analyses, the KBDP hasexamined des ated adverse outcomes. pi issible geographic andother local clusters (Village Park arid Ro al Kunia , and birth de&’cttrends and changes ever time At the national level, the HBDPers ed a’ the pilot site and in Phase II studies of the Department of(mIt \-\ arS\ itdrume Btrth Defects Stndr. The Pt’ograin alsopros ides inkrntatiuit for s ecial iiidies and for deselopine publicasvat’cttc” education pt’ogi-am. about birth JeL’cts and their causes.And lastl\. the HBDP acts as a res’urce t’r the plannine anddevelpnient ‘I appropriate statewide and cointnnnt lesel scrs icesand pIes elitis e strategies.Front 1 u(ss until 2i)i2, the HBDP a s covered under HaaaitRev ied Statutes FIRS. sections 321 l aiid 335-1. for its statutoryauthority, a ith additional lecislatioi FIRS 314-I and 324-2) addedin 1990 Amendments. During the 2002 Hawaii Legislative Session.Act 252 (513 2763. SD2, HD2, (‘Dl specifically relating to birthdetects) was enacted by the legislature, and signed by the Governoron July 1. 2002. Funding forthe Program has come through federal.state, and foundation public and private sources,‘The HBDP carries out its own research, culminating in data andinloritiation dissetnination to community requesters. presettiations.publications, and 22 articles published itt pritessional peer—re—vtea ed ,ionrnals.In I 000, the Pea- Fits it’ontnental Heal t It Coin mis’ion at the Johnshopkins School of Public Health. attd in 2002. the Trust forAmerica’s I Iealth. both cave the II B DP an A grade and designatedit as one of thetopeiaht programs in ihecountry. andoneofoitlr fournatiolla ide to meet all rating criteria,Neoplasms in Infants Diagnosed Under OneYear of Age in HawaiiThere are several reasons why a birth defects registry’ might collectinformation on neoplasms. Birth defects and neoplasms may has esimilar etiologies. For example. it has been suggested that sexhormones and their analogues might cause the birth defects hypos—padias and undescended testicle as well as testicular cancer.” Andneoplasms ma he prenatally’ diagnosed and electively terminated.Reaulai’ cancer/tumor registries do not normally’ identify these prebirth cases. while birth det’ects registries such as the HBDP thatinclude fetal demises. prenatally diagnosed cases and electis etertninations. include them as part ut’ their regular case ascertain—nient procedures. In addition. i’egular cancel/tumor registries t pm—calL do not include benign tumors such as lipontas. lfa birth detectsregistr\ includes benign tumor’, then it would serve as a source ofin format ion br such tu inors svhere a cancer/tumor rca istry- svou Idnot.The HBDP collects information on neoplasms. both benign andtnalianant. that are diagnosed beta een conception and one sear afterdelis cry . Excluding 15 I cases of cystic hygroma lvmphangioma I.a hich is strongix associated vs tb chroinosonial abnormalities andmay spontaneously resois e during pregnancy. ‘ the HBDP identi—tied an additional 114 cases of neoptasins diagnosed before age oneyear among deliveries during I 050-2000. In that time period theress ei’e 251 .66 total live births in Hasvaii, resulting in an infant amidfetus rieoplasm rate of 4.0 per l0.OOt) births, The most common typeof rieoplasm ss’as teratoma (n=2 I, 1 8.4ff-). follos-ved by lipoma(n=l 8. 15,8ff ), neurohlastoma(r=l4. l2.3ff-).retinohlastomatn=l 2.10.5’ . hepatoblastoma (n=8, 7.0ff . and medulloblastoma (n=5.44(4 Live births accortnted for 108 (04.7ff-) of the cases, ofsvhiclt12 ( II .1’, ) were knosvn to has e died ss ithin one year of age. Theremaining eases were evenly divided among elective terminationsn=3. la’ and fotal deaths (n3. 2.0’ , In I a I 4.0ff of the cases.the neoplasm vs as prenaiallx diagnosed ‘n ultraound.The number of infants and tdtuses a ith neoplasins s aried vs idelx byveat’. a tb a loss ol two amonc intaitts delisered in 2000 and a highIS in l’)OT There was no clear ‘ecular trend in neoplasm matesduring the I 5-year pei’iod ) p=11tt-\lth’neh the tteoplasm late among cases svith maternal ace lessthan .45 x eat’s 4.2 per 10.0(U) hit’ths ss as higher than the rate amongcases a iih maternal aceol35 years ‘‘rgreaieri3.i)pcr lt,).04i(i births’.the vlmtlerence was not statmsticullx sietn)icaitt ‘p0. 162 i. TIie rates39t 1 s ( 1 p i 10000 hi thH ani I m Ics (40 pci 10000ii h ) ‘ i siinil i 0 I isins xx ci s hs anti Oh t ioi pommon1 IlilpIL ho th (1 ‘pci l0.000hiths thin tm n’ sinelcionii ‘ii ° pci I HOt huths pHI ((OS UI the sc Fn cases ofP’ Ii,tiil’’fl’’ l1’iftiplc ho tlis. t1ici cxci .‘ i\\ 0 pans of lxxiii-.id all 01 the ilL splasin nc set ot ictin hI.istoina and one etIohListoiua1 ‘ “:i lii . itien”’ plasm etc xx a slcnln.nh1\ hiphci1 io” ii “ I ixeix 01 Icssth n 4Sxxccks8 8 i 1(1.1)1)0H’ I I xx ck i i 2 Op rIO 000hnthI I fx h t It of I tb n 00 r it is 14 ( pI,p ‘d I hn th x i’ht of “ 00 tm oipa 10 Ii> hittlis p 00 $i0 11’ of 1 )pl.,Oifs \\a imilai anion’ lcli\cnes to1 I l!0)”Tht iii Honolulu — I pci 11.11(H) niitlis and tb.f I t Hpct lii.lHttihnth.’ 11-3(1 15)1 I \Ithuueh the i,ltcsJ “J “nilix cnwtics ( it’ and( onnt\ of Honolulu 4.Opcr‘‘Ill I I,,o a 0 ‘uflt\ 4 pLI 115111(1) hirthsi. \lani C ounichnths id kauai ( ounix pLi (0000 hiilhsii x’ 1 ( I I itisti,. lix i’ mlicant.‘pI ii lic x ith i latci nal r Ic thntcitr ofI h. H xx i tt S into tid (juno tnt u 1 (4’ p rL d h I ilipi 0 4.’ pci 10 000 httths t anda 10 ( (I hi lb and lox xi imonc [-‘at F’asi Asians( 1iii ‘if Kocaiio per l)(,0)Iflhiiihsi Hoxxcxci,I i5 ic etc H not tatlstiL dir sinniticani.fix ...‘\ I, , I 01 ihe mtant’. and fetuses had L\ toceH 1’ i’ ‘L’itOIOid (If thcs low \xcie found to haxe“1 ‘I ,t.tI ‘On ‘in ‘I0t parliat H isonir 2 ii clinohiasluina)P I ILl lot ‘said H ,son, 19 Ocnkmi t) an I lianslo0110 1’ 1. if Ill Icnk iito Filir lou (4, .4 Hol thhr ‘ 0 t iii I I ‘ s. Th inoic common majorI U. 1 ‘ i hr Iro phd\ In ill mt roccphahI I ito if i td dL t (in.Si t ) of the casd( ii” 1 .iitt Icc — Rnss II Silici scndi iii’. Klippcl- ‘. ,-nt,aeion, Beck’ tloc\ icdciiiaiin s\ilUioIIlc.H 11. -\1. cc a’ Iioin . no-I i.d-di coal sx ndi oine. and‘11’ iii!’ Ii.S a I 1,110011 .11’ ., f,’t (nm th Haxxaii I-huh 1) Iccts Pm0 11.110’ th I lullIStOltot th 1) \IeuiI ii. ‘ ) H 1 1 H 019 7 1 I 50I ‘I ) 81 ( I hh (‘ u h 1 ‘i it do) x’ titi IRfeFencesa p-’ 7 T in P P pp T ‘,Z M P ‘ a, (‘ I of r , m’d trcmI I, a I’” a m p cc p H’ ,o’ p’U,tr c’ bI H c-a‘-‘F PH, “ L - aI’ .i co r”I’,1, .,OAHU: 941-4411NEIGHBOR ISLANDS TOLL-FREE:1-800-362-3585Free Hotline 24 Hours a Day.POISON CENTER TIPS• Keep the number of the Hawaii Poison Center onor near your telephone.• if you suspect a poisoning, do not wait for signsand symptoms to develop. Call the Hawaii PoisonCenter immediately.• Always keep Ipecac Syrup in your home, (This isused to make a person vomit in certain types ofpoisoning.) Do use ipecac Syrupunless advised by the Hawaii PoisonCenter.• Store all medicines, chemicals, and householdproducts out of reach and out 0f sight, preferablylocked up.• A good rule to teach children is to “always askfirst” before eating or drinking anything-—don’ttouch, don’t smell, don’t taste.Donate to help us save lives.Mail checks, payable to:Hawaii Poison Center1319 Pjch Street Honolulu. HI 9o82o

Description of neoplasms in infants diagnosed under one year of age in Hawaii, 1986-2000.

http://evols.library.manoa.hawaii.edu/bitstream/10524/53651/1/2003-02p39-40.pdf

Description of neoplasms in infants diagnosed under one year of age in Hawaii, 1986-2000.

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eVols at University of Hawaii at Manoa