Presented on December 13, 2016 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering and Bioscience (IBB), room 1128, Georgia Tech.Steven L. Goudy is an Associate Professor, Otolaryngology – Head & Neck Surgery at Emory University and Director, Division of Pediatric Otolaryngology,
Children's Healthcare of Atlanta.CLINICAL FOCUS - While I provide comprehensive and compassionate care to all of my patients, I have a particular interest in treating development and neoplastic concerns of the head and neck region. Such craniofacial development abnormalities as cleft lip and palate, Pierre Robin Sequence, and velopharyngeal insufficiency
are also a strong focus of my practice. Multidisciplinary collaboration is an
important mechanism in my treatment approach, an example being my
participation in teams of diverse specialists that evaluate and treat patients
with vascular and neonplastic tumors of the head and neck region.
RESEARCH FOCUS - Cleft and craniofacial disorders are my primary clinical and basic research interests. Even though the surgical repair of cleft lip and palate is highly effective, patients will continue to be faced with ongoing medical, dental, and
surgical care. Surgical outcomes can be variable, and the patient's facial
growth and development is primarily the result of their genetic composition.
Therefore, much of my research focuses on the problems that can develop
during the years that follow surgery. Underdevelopment of the upper jaw is one of the main sequelae of cleft
palate repair and causes maxillary hypoplasia. To uncover why this
happens, I have assembled a team of collaborators that includes Drs. Nick
Willett (Emory Department of Orthopedics), Gregory Gibson (Center for
Integrative Genomics, Georgia Institute of Technology), and Michael Davis
(Coulter Department of Biomedical Engineering at Georgia Tech and Emory
University), all of whom are experts in the fields of bone and vascular
biology. Our goal is to determine how cell autonomous and noncell
autonomous Jagged1 signaling during maxillary development contributes to
final maxillary formation. I worked closely with Dr. Joey Barnett of the Department of Pharmacology at
Vanderbilt while I was there, and he will continue to be my senior advisor as I
evaluate the integration of Jagged1 and TgfßR3 signaling during maxillary
mesenchymal cell differentiation and ossification. With assistance from Drs. Scott Boden (Emory Department of Orthopedics),
Roberto Pacifici (Emory Department of Medicine), and Bob Taylor (Emory
Department of Medicine), I am examining how intramembranous ossification
of the maxillary and palatine bones contributes to later maxillary morphology.
Dr. Greg Gibson (Director of the Center for Integrative Genomics, Georgia
Tech) will help plan, execute, and analyze the RNAseq
data to identify the
targets of Jagged1 signaling. We have already published our observations
involving the bony phenotype and our conclusion that Wnt1Cre;Jagged1
F/F
mice are a viable model of postnatal
maxillary hypoplasia. Once we have a
wider understanding of maxillary development, we plan on developing
targeted therapies for future in vitro and in vivo correction of maxillary
hypoplasia in the Jag1CKO mice.Runtime: 62:03 minute
