In the title compound, C32H24F4N2O, all four six-membered rings that constitute the diazaadamantanone cage adopt chair conformations. Two of the four fluorophenyl substituents occupy axial positions and the other two occupy equatorial positions relative to their respective C5N rings of the adamantane framework. The crystal structure is stabilized by C—H⋯O interactions, generating a C(5) chain along the a axis