Acknowledgements: The Panel wishes to thank the members of the Working Group on HBGV for mycotoxins and their modified forms: Jan Alexander, Chiara Dall'Asta, Arno Gutleb, Manfred Metzler, Isabelle Oswald and Dominique Parent-Massin for the preparatory work on this scientific opinion, and the EFSA staff members: Marco Binaglia and Hans Steinkellner for the support provided to this scientific opinion.Peer reviewedPublisher PD

Alexander, Jan

Barregård, Lars

Bignami, Margherita

Binaglia, Marco

Brüschweiler, Beat

Ceccatelli, Sandra

Cottrill, Bruce

Dall'Asta, Chiara

Dinovi, Michael

Edler, Lutz

EFSA Panel on Contaminants in the Food Chain (CONTAM)

Grasl-Kraupp, Bettina

Gutleb, Arno

Hogstrand, Christer

Hoogenboom, Laurentius (Ron)

Knutsen, Helle Katrine

Metzler, Manfred

Nebbia, Carlo Stefano

Oswald, Isabelle

Parent-Massin, Dominique

Petersen, Annette

Rose, Martin

Roudot, Alain-Claude

Schwerdtle, Tanja

Steinkellner, Hans

Vleminckx, Christiane

Vollmer, Günter

Wallace, Heather

EFSA Journal

Acknowledgements: The Panel wishes to thank the members of the Working Group on HBGV for mycotoxins and their modified forms: Jan Alexander, Chiara Dall'Asta, Arno Gutleb, Manfred Metzler, Isabelle Oswald and Dominique Parent-Massin for the preparatory work on this scientific opinion, and the EFSA staff members: Marco Binaglia and Hans Steinkellner for the support provided to this scientific opinion.Peer reviewe

Aberdeen University Research

English

Appropriateness to set a group health based guidance value for T2 and HT2 toxin and its modified forms

International audienceThe EFSA Panel on Contaminants in the Food Chain (CONTAM) established a tolerable daily intake (TDI) for T2 and HT2 of 0.02 lg/kg body weight (bw) per day based on a new in vivo subchronic toxicity study in rats that confirmed that immune-and haematotoxicity are the critical effects of T2 and using a reduction in total leucocyte count as the critical endpoint. An acute reference dose (ARfD) of 0.3 lg for T2 or T2/kg bw was established based on acute emetic events in mink. Modified forms of T2 and HT2 identified are phase I metabolites mainly formed through hydrolytic cleavage of one or more of the three ester groups of T2. Less prominent hydroxylation reactions occur predominantly at the side chain. Phase II metabolism involves conjugation with glucose, modified glucose, sulfate, feruloyl and acetyl groups. The few data on occurrence of modified forms indicate that grain products are their main source. The CONTAM Panel found it appropriate to establish a group TDI and a group ARfD for T2 and HT2 and its modified forms. Potency factors relative to T2 for the modified forms were used to account for differences in acute and chronic toxic potencies. It was assumed that conjugates (phase II metabolites of T2, HT2 and their phase I metabolites), which are not toxic per se, would be cleaved releasing their aglycones. These metabolites were assigned the relative potency factors (RPFs) of their respective aglycones. The RPFs assigned to the modified forms were all either 1 or less than 1. The uncertainties associated with the present assessment are considered as high. Using the established group, ARfD and TDI would overestimate any risk of modified T2 and HT2

Oswald, Isabelle P.

Knutsen, Helle‐Katrine

Grasl‐Kraupp, Bettina

Hoogenboom, Laurentius,

Nebbia, Carlo,

Roudot, Alain‐Claude

Parent‐Massin, Dominique

HAL Descartes

The EFSA Panel on Contaminants in the Food Chain (CONTAM) established a tolerable daily intake (TDI) for T2 and HT2 of 0.02 μg/kg body weight (bw) per day based on a new in vivo subchronic toxicity study in rats that confirmed that immune- and haematotoxicity are the critical effects of T2 and using a reduction in total leucocyte count as the critical endpoint. An acute reference dose (ARfD) of 0.3 μg for T2 and HT2/kg bw was established based on acute emetic events in mink. Modified forms of T2 and HT2 identified are phase I metabolites mainly formed through hydrolytic cleavage of one or more of the three ester groups of T2. Less prominent hydroxylation reactions occur predominantly at the side chain. Phase II metabolism involves conjugation with glucose, modified glucose, sulfate, feruloyl and acetyl groups. The few data on occurrence of modified forms indicate that grain products are their main source. The CONTAM Panel found it appropriate to establish a group TDI and a group ARfD for T2 and HT2 and its modified forms. Potency factors relative to T2 for the modified forms were used to account for differences in acute and chronic toxic potencies. It was assumed that conjugates (phase II metabolites of T2, HT2 and their phase I metabolites), which are not toxic per se, would be cleaved releasing their aglycones. These metabolites were assigned the relative potency factors (RPFs) of their respective aglycones. The RPFs assigned to the modified forms were all either 1 or less than 1. The uncertainties associated with the present assessment are considered as high. Using the established group, ARfD and TDI would overestimate any risk of modified T2 and HT2

Knutsen, Helle-Katrine

Hoogenboom, L.A.P.

Dall'asta, Chiara

NARCIS 

Scientific opinion: Appropriateness to set a group health based guidance value for T2 and HT2 toxin and its modified forms

Barregård, Lars

Brüschweiler, Beat

Vollmer, Günter

Archivio istituzionale della Ricerca -  Università degli Studi di Parma

Appropriateness to set a group health based guidance value for T2 and HT2 toxin and its modified forms

Abstract

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Aberdeen University Research

HAL Descartes

NARCIS

Archivio istituzionale della Ricerca - Università degli Studi di Parma