Background: The increasing tendency of Neisseria gonorrhea’s Ceftriaxoneresistant
through the years had pushed medical experts to search for alternate
regiment for the treatment of Gonorrhea. Azithromycin is one of the alternative
options.
Purpose: To assess the difference in sensitivity for Neisseria gonorrhoeae
towards Azithromycin and Kanamycin in vitro.
Materials & Methods: A cross sectional, analytic observational study which
examined 13 subjects with positive purulent discharge. The samples undergo
gram staining to find negative gram diplococcic bacteria, followed by a Thayer-
Martin culture and a 24-hours incubation on 370C temperature. The colony
samples were then moved to a Mueller Hinton media for both Azithromycin and
Ceftriaxone sensitivity testing. After the second 24-hours incubation, any
inhibition zone formed on the colony samples was being measured. Statistical
analysis uses chi-square test.
Result: Azithromycin has 7 (53,5%) sensitive Neisseria gonorrheae samples while
the 6 (46,2%) others were resistant. Ceftriaxone were shown resistant to 12
(92,3%) samples and only 1 (7,7%) sample was sensitive.
Conclusion: There is a marked difference in sensitivity for Neisseria gonorrheae
towards Azithromycin and Ceftriaxone in vitro, where Azithromycin shows higher
sensitivity measure.
Keywords: gonorrhea, Neisseria gonorrhoeae, azithromycin, ceftriaxon
