In the title compound, C21H21N3O4S, the cyclohexane ring adopts a chair conformation. The nitro and methylphenyl groups are all coplanar with the indole ring system. Intramolecular N—H⋯O and C—H⋯S hydrogen bonds generate S(6) ring motifs. The molecules form R
2
2(20) centrosymmetric dimers via intermolecular C—H⋯O hydrogen bonds. A short O⋯O contact [2.842 (2) Å] is observed in the dimer