Higuchi, Mitsuru

Kanda, Atsushi

Kawanaka, Kentaro

Koga, Jinichiro

Morifuji, Masashi

English

PubMed

Atsushi Kanda

Masashi Morifuji

Jinichiro Koga

Kentaro Kawanaka

Mitsuru Higuchi

Crossref

Journal of the International Society of Sports Nutrition

Long-term feeding of whey protein hydrolysates increases skeletal muscle glycogen levels and improves exercise performance in mice

Kanda Atsushi

Morifuji Masashi

Koga Jinichiro

Kawanaka Kentaro

Higuchi Mitsuru

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POSTER PRESENTATION Open Access
Long-term feeding of whey protein hydrolysates
increases skeletal muscle glycogen levels and
improves exercise performance in mice
Atsushi Kanda1*, Masashi Morifuji1, Jinichiro Koga1, Kentaro Kawanaka2, Mitsuru Higuchi3
From International Society of Sports Nutrition; 7th Annual ISSN Conference and Expo
Clearwater Beach, FL, USA. 24-26 June 2010
Background
Recently, our studies have shown that co-ingestion of
carbohydrate and whey protein hydrolysate (WPH) is
more effective for increasing post-exercise skeletal mus-
cle glycogen content than ingestion of other protein
sources (whey protein, casein hydrolysate, or branched
chain amino acids). We have also shown that chronic
feeding of whey protein increases glycogen contents in
skeletal muscle of exercise-trained rats to a greater extent
than does casein. To confirm our hypothesis that long-
term feeding of WPH is more effective for increasing
both muscle glycogen content and exercise performance
than other protein sources, we compared long-term feed-
ing of WPH to other protein sources for their effects on
skeletal muscle glycogen levels and exercise performance.
Methods
Male ddY mice were divided into three groups and
allowed free access to water and diet containing either
whey protein, WPH, or casein for five weeks. During
this period, the mice were exercised in a pool five times
a week, with exercise performance being measured once
a week. On the final day of the five week experiment,
the mice were killed for analysis of glycogen content in
the gastrocnemius muscle.
Results
The WPH group showed a significant increase (p <
0.05) in exercise performance (42.35+/-5.11 min) com-
pared with the casein group (28.47+/-1.96 min).
Furthermore, skeletal muscle glycogen levels were
higher in the WPH group (4.42+/-0.24 mg/g) than in
either the whey protein (3.39+/-0.40 mg/g, p < 0.05) or
casein group (2.60+/-0.18 mg/g, p< 0.01).
Conclusion
These results indicate that long-term feeding of WPH is
more effective for increasing glycogen content in skeletal
muscle, and improving exercise performance than other
protein sources.
Author details
1Food and Health R&D Laboratories, Meiji Seika Kaisha Ltd., 5-3-1 Chiyoda,
Sakado-shi, Saitama 350-0289, Japan . 2Department of Health and Nutrition,
Niigata University of Health and Welfare, 1398 Shimamicho, Kita-ku, Niigata,
Niigata 950-3198, Japan . 3Faculty of Sport Sciences, Waseda University,
135-1 Horinouchi, Tokorozawa, Saitama 359-1165, Japan.
Published: 15 September 2010
doi:10.1186/1550-2783-7-S1-P20
Cite this article as: Kanda et al.: Long-term feeding of whey protein
hydrolysates increases skeletal muscle glycogen levels and improves
exercise performance in mice. Journal of the International Society of Sports
Nutrition 2010 7(Suppl 1):P20.
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1Food and Health R&D Laboratories, Meiji Seika Kaisha Ltd., 5-3-1 Chiyoda,
Sakado-shi, Saitama 350-0289, Japan
Full list of author information is available at the end of the article
Kanda et al. Journal of the International Society of Sports Nutrition 2010, 7(Suppl 1):P20
http://www.jissn.com/content/7/S1/P20
© 2010 Kanda et al;licensee BioMed Central Ltd.


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Long-term feeding of whey protein hydrolysates increases skeletal muscle glycogen levels and improves exercise performance in mice

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