OBJECTIVE - To study mortality in relation to fasting plasma glucose (FPG) and 2-h plasma glucose levels within the normoglycemic range

A. Onat

Abdul-Ghani

Barr

Bogardus

Coutinho

DECODE Study Group

DECODE Study Group, on behalf of the European Diab

DeFronzo

F. Ning

J. Tuomilehto

K. Pyorala

Kannel

McGee

Q. Qiao

Qiao

S. Soderberg

Shahab

Stamler

Succurro

The DECODE Study Group

English

PubMed

Pyorala, Kalevi

Qiao, Qing

Tuomilehto, Jaakko

Onat, Altan

Soderberg, Stefan

Ning, Feng

İstanbul Üniversitesi Açık Erişim Sistemi

Diabetes Care

Cardiovascular Disease Mortality in Europeans in Relation to Fasting and 2-h Plasma Glucose Levels Within a Normoglycemic Range

Ning F

Tuomilehto J

Pyörälä K

Onat A

Söderberg S

Qiao Q

Julkari

Cardiovascular disease mortality in Europeans in relation to fasting and 2-h plasma glucose levels within a normoglycemic range

OBJECTIVE To study mortality in relation to fasting plasma glucose (FPG) and 2-h plasma glucose levels within the normoglycemic range. RESEARCH DESIGN AND METHODS Data from 19 European cohorts comprising 12,566 men and 10,874 women who had FPG &lt;6.1 mmol/l and 2-h plasma glucose &lt;7.8 mmol/l at baseline examination were analyzed. Multivariate-adjusted hazard ratios (HRs) and 95% CIs for deaths from cardiovascular disease (CVD), non-CVD, and all causes were estimated for individuals whose 2-h plasma glucose &gt; FPG (group II) compared with those whose 2-h plasma glucose ≤ FPG (group I). RESULTS A total of 827 (246) CVD and 611 (351) non-CVD and 1,438 (597) all-cause deaths occurred in men (women). Group II was older and had higher BMI, blood pressure, and fasting insulin than group I. The multivariate-adjusted HRs (95% CIs) for CVD, non-CVD, and all-cause mortality were 1.22 (1.05–1.41), 1.09 (0.92–1.29), and 1.16 (1.04–1.30) in men and 1.40 (1.03–1.89), 0.99 (0.79–1.25), and 1.13 (0.94–1.35) in women, respectively, for group II as compared with group I. HRs were 1.25 (1.05–1.50), 1.09 (0.89–1.34), and 1.18 (1.03–1.35) in men and 1.60 (1.03–2.48), 1.05 (0.78–1.42), and 1.18 (0.93–1.51) in women, respectively, after additional adjustment for fasting insulin in a subgroup of individuals. CONCLUSIONS In individuals with both FPG and 2-h plasma glucose within the normoglycemic range, high 2-h plasma glucose was associated with insulin resistance and increased CVD mortality.</p

Ning, Feng,

Tuomilehto, Jaakko,

Pyörälä, Kalevi,

Onat, Altan,

Söderberg, Stefan,

Qiao, Qing,

Swepub

Crossref

Age- and sexspeciﬁc prevalences of diabetes and imNing and Associates care.diabetesjournals.org DIABETES CARE,

AlbertiKG,Pyo ¨ra ¨la ¨ K,ZetheliusB,Stegmayr B, DECODE Study Group. Hyperglycemia and stroke mortality: comparison between fasting and 2-h glucose criteria. Diabetes Care

Cell function in subjects spanning the range fromnormalglucosetolerancetoovertdiabetes: a new analysis.

Comparison of different deﬁnitions of the metabolic syndrome in relation to cardiovascular mortality

Continuous relationshipsbetweennon-diabetichyperglycaemia and both cardiovascular disease andall-causemortality:theAustralianDiabetes, Obesity, and Lifestyle (AusDiab) study.

Diabetes and cardiovascular disease. The Framingham study.

Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia. Report of a World Health Organization/International Diabetes Federation Consultation. Geneva, World Health Organization,

diagnostic criteria for diabetes mellitus change phenotype of patients withdiabetes?ReanalysisofEuropeanepidemiological data.

Differences in cardiovascular risk proﬁle based on relationship between post-load plasma glucose and fasting plasma levels. Diabetes Metab Res Rev

Diverse Populations Collaboration. Body mass index and mortality: a meta-analysis based on person-level data from twenty-six observational studies. Ann Epidemiol

European Diabetes Epidemiology Group. Is the current deﬁnition for diabetes relevant to mortality risk from all causes and cardiovascular and noncardiovascular diseases? Diabetes Care

Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria. DECODE Study Group. The European Diabetes Epidemiology Group. Diabetes Epidemiology: Collaborative Analysis of Diagnostic Criteria in Europe.

Group. The European Diabetes Epidemiology Group. Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria.

Impaired fasting glucose, blood pressure and cardiovascular disease mortality.

Low fasting plasma glucoselevelasapredictorofcardiovascular disease and all-cause mortality.

mortality from all causes and from cardiovascular disease in ﬁve populations of Asian origin.

other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993;16:

QiaoQ,Pyo ¨ra ¨la ¨ K,Pyo ¨ra ¨la ¨ M,NissinenA, Lindstro ¨m

Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects.

Risk of progression to type 2 diabetes based on relationship between postload plasma glucose and fasting plasma glucose.

Simonson DC.Fastinghyperglycemiainnon-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism

The relationship between glucose and incident cardiovascular events. A metaregressionanalysisofpublisheddatafrom 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care 1999;22:

Why does diabetes mellitus increase the risk of cardiovascular disease?

World Health Organization-International Society of Hypertension guidelines for the management of hypertension. Guidelines subcommittee.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2945162

Cardiovascular Disease Mortality in Europeans in Relation to Fasting and 2-h Plasma Glucose Levels Within a Normoglycemic Range

Abstract

Similar works

Full text

Available Versions

İstanbul Üniversitesi Açık Erişim Sistemi

Julkari

Swepub

Julkari

Crossref