CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
β1-Syntrophin Modulation by miR-222 in mdx Mice
Authors
A De Luca
AA Hack
+56 more
AA Hack
AH Ahn
AH Williams
B Cardinali
B Gavillet
C Le Sage
Carlo Cogoni
D Leonoudakis
D Sandonà
DP Bartel
E Gazzerro
E Mattei
E Ozawa
Elisabetta Vivarelli
EP Hoffman
F Duclos
F Fornari
F Sciandra
Fabio Naro
Filippo Serra
G Bonuccelli
G Bonuccelli
G Bulfield
H Komati
I Eisenberg
I Eisenberg
JF Chen
JF Chen
JJ McCarthy
JM Ervasti
K Araishi
K Ohlendieck
K Okuhira
KA Lapidos
KE Davies
KH Holt
KJ Jones
KK Tomczak
L Matthew
L Monaco
Lucia Monaco
M Donà
M Durbeej
Maria Moran
MD Grounds
MF Peters
MJ Allikina
R Barresi
S Greco
SH Gee
TE Callis
Valeria De Arcangelis
VN Kim
W Filipowicz
WD Biggar
Z Chen
Publication date
1 January 2010
Publisher
Public Library of Science
Doi
Cite
View
on
PubMed
Abstract
Background: In mdx mice, the absence of dystrophin leads to the deficiency of other components of the dystrophin-glycoprotein complex (DAPC), making skeletal muscle fibers more susceptible to necrosis. The mechanisms involved in the disappearance of the DAPC are not completely understood. The muscles of mdx mice express normal amounts of mRNA for the DAPC components, thus suggesting post-transcriptional regulation. Methodology/Principal Findings: We investigated the hypothesis that DAPC reduction could be associated with the microRNA system. Among the possible microRNAs (miRs) found to be upregulated in the skeletal muscle tissue of mdx compared to wt mice, we demonstrated that miR-222 specifically binds to the 3′-UTR of β1-syntrophin and participates in the downregulation of β1-syntrophin. In addition, we documented an altered regulation of the 3′-UTR of β1-syntrophin in muscle tissue from dystrophic mice. Conclusion/Significance: These results show the importance of the microRNA system in the regulation of DAPC components in dystrophic muscle, and suggest a potential role of miRs in the pathophysiology of dystrophy. © 2010 De Arcangelis et al
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Public Library of Science (PLOS)
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 18/09/2018
Directory of Open Access Journals
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:doaj.org/article:6f01955e5...
Last time updated on 13/10/2017
Crossref
See this paper in CORE
Go to the repository landing page
Download from data provider
info:doi/10.1371%2Fjournal.pon...
Last time updated on 03/01/2020
Archivio della ricerca- Università di Roma La Sapienza
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:iris.uniroma1.it:11573/364...
Last time updated on 12/11/2016