Ding, Guohui

Dong, Xiao

Li, Yixue

Wang, Zhen

Genetics Selection Evolution

English

PubMed

Abstract
          
            Background
            Multiple models have been proposed to interpret the retention of duplicated genes. In this study, we attempted to compare whether the duplicates arising from tandem duplications and retropositions are retained by the same mechanisms in human and mouse genomes.
          
          
            Results
            Both sequence and expression similarity analyses revealed that tandem duplicates tend to be more conserved, whereas retrogenes tend to be more divergent. The duplicability of tandem duplicates is also higher than that of retrogenes. However, positive selection seems to play significant roles in the retention of both types of duplicates.
          
          
            Conclusions
            We propose that dosage effect is more prevalent in the retention of tandem duplicates, while 'escape from adaptive conflict' (EAC) effect is more prevalent in the retention of retrogenes.
          </jats:sec

Zhen Wang

Xiao Dong

Guohui Ding

Yixue Li

Crossref

Comparing the retention mechanisms of tandem duplicates and retrogenes in human and mouse genomes

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Comparing the retention mechanisms of tandem duplicates and retrogenes in human and mouse genomes

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Springer - Publisher Connector

Springer - Publisher Connector