Effects of Sildenafil and Tadalafil on Intraocular Pressure in Sheep: Implications for Aqueous Humor Dynamics

Abstract

These results showing that oral administration of sildenafil and tadalafil increased sheep IOP (with a longer-lasting IOP elevation with the latter agent) are novel findings. The results are discussed within the context of a modified model for AH dynamics that may be of particular importance to senior individuals, the group most likely to be treated with these compounds for vascular diseases